Simulation scenario 1, CR phase

Setting description

Treatments equally effective across the biomarker signatures

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 9 5 3 2 TP53- & AR- 53 37 23 31 TP53+ 13 5 2 5 DRD+ 6 1 3 1 TEfus+ 5 5 1 6

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.018 0.010 0.006 0.004 TP53- & AR- 0.106 0.074 0.046 0.062 TP53+ 0.026 0.010 0.004 0.010 DRD+ 0.012 0.002 0.006 0.002 TEfus+ 0.010 0.010 0.002 0.012

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 11 2 1 1 TP53- & AR- 132 121 134 125 TP53+ 26 31 26 22 DRD+ 18 28 24 26 TEfus+ 23 38 28 25

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.022 0.004 0.002 0.002 TP53- & AR- 0.264 0.242 0.268 0.250 TP53+ 0.052 0.062 0.052 0.044 DRD+ 0.036 0.056 0.048 0.052 TEfus+ 0.046 0.076 0.056 0.050

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 20 15 19 18 TP53+ 1 11 7 12 DRD+ 0 0 0 0 TEfus+ 0 0 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.040 0.030 0.038 0.036 TP53+ 0.002 0.022 0.014 0.024 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.000 0.000

Errors & power

The overall error was 0.37.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.168             0.104             0.058             0.086 

The overall power was .
The corresponding power separate for the different treatments were:

NULL

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	9	5	3	2
	futility	0	11	2	1	1
	max_n	0	0	0	0	0
	n	411 (377, 451)	185 (125, 252)	192 (137, 254)	193 (137, 257)	189 (135, 257)
	n_unique	377 (345, 411)	170 (113, 235)	174 (125, 234)	176 (124, 239)	171 (121, 236)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	4 (4, 6)	5 (5, 8)	6 (5, 12)	9 (8, 12)
	post_p	NA (NA, NA)	0.49 (0.11, 0.87)	0.49 (0.08, 0.87)	0.47 (0.1, 0.88)	0.48 (0.09, 0.88)
	rate	0.112 (0.104, 0.119)	0.113 (0.103, 0.125)	0.113 (0.102, 0.125)	0.113 (0.102, 0.125)	0.112 (0.101, 0.127)
TP53- & AR-	graduation	0	53	37	23	31
	futility	0	132	121	134	125
	max_n	0	20	15	19	18
	n	172 (149, 199)	69 (27, 135)	66 (28, 119)	68 (28, 128)	70 (27, 128)
	n_unique	158 (137, 183)	63 (25, 127)	60 (25, 110)	63 (26, 120)	64 (25, 120)
	time_trial	36 (36, 36)	36 (10, 36)	36 (16, 36)	36 (16, 36)	36 (18, 36)
	time_stop	NA (NA, NA)	15 (7, 29)	18 (11, 31)	21 (12, 33)	22 (12, 32)
	post_p	NA (NA, NA)	0.48 (0.1, 0.89)	0.45 (0.08, 0.88)	0.5 (0.08, 0.88)	0.48 (0.09, 0.9)
	rate	0.112 (0.099, 0.125)	0.113 (0.095, 0.141)	0.114 (0.096, 0.146)	0.114 (0.096, 0.141)	0.114 (0.095, 0.143)
TP53+	graduation	0	13	5	2	5
	futility	0	26	31	26	22
	max_n	0	1	11	7	12
	n	180 (158, 206)	85 (46, 118)	89 (55, 125)	89 (58, 124)	85 (57, 122)
	n_unique	166 (143, 188)	77 (40, 108)	81 (49, 115)	81 (52, 114)	78 (51, 111)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	12 (9, 24)	16 (10, 34)	20 (13, 32)	21 (11, 33)
	post_p	NA (NA, NA)	0.48 (0.11, 0.86)	0.49 (0.09, 0.9)	0.49 (0.11, 0.85)	0.49 (0.09, 0.86)
	rate	0.112 (0.1, 0.125)	0.112 (0.098, 0.136)	0.113 (0.098, 0.133)	0.113 (0.098, 0.133)	0.113 (0.098, 0.135)
DRD+	graduation	0	6	1	3	1
	futility	0	18	28	24	26
	max_n	0	0	0	0	0
	n	110 (94, 125)	49 (29, 70)	52 (32, 71)	62 (44, 82)	61 (43, 81)
	n_unique	99 (85, 116)	43 (25, 64)	47 (29, 65)	55 (39, 75)	56 (39, 73)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	24 (17, 33)	29 (21, 34)	20 (9, 29)	21 (12, 32)
	post_p	NA (NA, NA)	0.48 (0.13, 0.86)	0.48 (0.12, 0.83)	0.48 (0.12, 0.89)	0.48 (0.12, 0.86)
	rate	0.112 (0.099, 0.128)	0.113 (0.093, 0.141)	0.114 (0.094, 0.143)	0.113 (0.096, 0.137)	0.114 (0.096, 0.139)
TEfus+	graduation	0	5	5	1	6
	futility	0	23	38	28	25
	max_n	0	0	0	0	0
	n	150 (130, 169)	68 (38, 94)	77 (48, 105)	73 (48, 100)	72 (47, 100)
	n_unique	136 (118, 155)	61 (34, 85)	71 (45, 95)	66 (42, 90)	66 (43, 91)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	20 (12, 33)	20 (10, 34)	22 (14, 30)	20 (13, 35)
	post_p	NA (NA, NA)	0.45 (0.1, 0.86)	0.48 (0.11, 0.86)	0.46 (0.1, 0.87)	0.46 (0.09, 0.86)
	rate	0.111 (0.1, 0.125)	0.113 (0.096, 0.137)	0.113 (0.096, 0.136)	0.113 (0.097, 0.136)	0.114 (0.096, 0.137)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	203	165	161	158
	futility	0	0	0	0	0
	max_n	0	20	15	19	18
	n	110 (92, 131)	38 (18, 98)	34 (11, 85)	36 (11, 88)	36 (11, 91)
	n_unique	102 (84, 122)	35 (17, 94)	32 (9, 81)	34 (10, 84)	34 (9, 88)
	post_p	NA (NA, NA)	0.46 (0.1, 0.88)	0.44 (0.09, 0.88)	0.45 (0.1, 0.86)	0.45 (0.11, 0.9)
	rate	0.112 (0.098, 0.13)	0.115 (0.095, 0.152)	0.116 (0.095, 0.194)	0.117 (0.094, 0.181)	0.116 (0.092, 0.172)
—+	graduation	0	214	188	171	177
	futility	0	0	0	0	0
	max_n	0	20	15	19	18
	n	20 (15, 27)	7 (3, 19)	9 (3, 21)	8 (2, 19)	8 (2, 19)
	n_unique	19 (13, 25)	7 (2, 17)	8 (3, 19)	7 (2, 18)	7 (2, 17)
	post_p	NA (NA, NA)	0.45 (0.17, 0.79)	0.44 (0.17, 0.84)	0.46 (0.21, 0.79)	0.45 (0.2, 0.83)
	rate	0.112 (0.081, 0.155)	0.122 (0.077, 0.244)	0.12 (0.081, 0.268)	0.124 (0.081, 0.275)	0.121 (0.078, 0.29)
–+-	graduation	0	58	43	32	30
	futility	0	0	0	0	0
	max_n	0	1	11	7	12
	n	62 (49, 76)	24 (9, 55)	25 (7, 53)	27 (8, 56)	24 (7, 52)
	n_unique	57 (44, 71)	23 (9, 52)	23 (6, 49)	25 (7, 52)	21 (6, 49)
	post_p	NA (NA, NA)	0.46 (0.12, 0.87)	0.43 (0.1, 0.88)	0.48 (0.13, 0.85)	0.41 (0.13, 0.86)
	rate	0.112 (0.092, 0.137)	0.118 (0.092, 0.183)	0.122 (0.089, 0.214)	0.116 (0.089, 0.197)	0.122 (0.092, 0.22)
–++	graduation	0	83	72	54	58
	futility	0	0	0	0	0
	max_n	0	1	10	7	11
	n	42 (32, 53)	15 (5, 36)	20 (8, 41)	15 (5, 35)	15 (5, 35)
	n_unique	38 (28, 49)	13 (5, 33)	18 (7, 37)	14 (4, 32)	14 (4, 32)
	post_p	NA (NA, NA)	0.44 (0.13, 0.84)	0.47 (0.13, 0.85)	0.41 (0.12, 0.86)	0.42 (0.13, 0.82)
	rate	0.11 (0.088, 0.139)	0.12 (0.087, 0.223)	0.116 (0.087, 0.195)	0.122 (0.085, 0.263)	0.12 (0.085, 0.253)
-+–	graduation	0	217	182	171	172
	futility	0	0	0	0	0
	max_n	0	20	15	19	18
	n	20 (14, 27)	7 (1, 18)	8 (2, 18)	9 (3, 20)	9 (4, 21)
	n_unique	18 (13, 25)	6 (1, 17)	7 (2, 16)	8 (3, 19)	8 (3, 19)
	post_p	NA (NA, NA)	0.45 (0.19, 0.83)	0.47 (0.21, 0.79)	0.49 (0.18, 0.85)	0.44 (0.17, 0.83)
	rate	0.113 (0.083, 0.159)	0.124 (0.075, 0.324)	0.124 (0.081, 0.272)	0.12 (0.076, 0.249)	0.125 (0.078, 0.237)
-+-+	graduation	0	228	201	180	188
	futility	0	0	0	0	0
	max_n	0	20	15	19	18
	n	20 (14, 27)	6 (1, 17)	7 (2, 18)	9 (4, 20)	9 (4, 20)
	n_unique	19 (13, 25)	5 (1, 16)	6 (2, 17)	8 (3, 18)	8 (3, 18)
	post_p	NA (NA, NA)	0.47 (0.19, 0.84)	0.44 (0.17, 0.82)	0.48 (0.17, 0.83)	0.44 (0.17, 0.84)
	rate	0.114 (0.079, 0.16)	0.124 (0.074, 0.306)	0.127 (0.071, 0.294)	0.121 (0.08, 0.26)	0.122 (0.08, 0.242)
-++-	graduation	0	79	62	54	53
	futility	0	0	0	0	0
	max_n	0	1	11	7	12
	n	11 (7, 16)	5 (1, 11)	5 (2, 11)	6 (3, 12)	6 (3, 12)
	n_unique	10 (6, 15)	4 (1, 10)	4 (1, 10)	6 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.48 (0.22, 0.8)	0.47 (0.23, 0.82)	0.47 (0.2, 0.81)	0.45 (0.2, 0.8)
	rate	0.114 (0.071, 0.182)	0.127 (0.065, 0.307)	0.125 (0.064, 0.323)	0.126 (0.072, 0.292)	0.13 (0.073, 0.299)
-+++	graduation	0	102	89	72	76
	futility	0	0	0	0	0
	max_n	0	1	10	7	11
	n	11 (7, 17)	5 (1, 11)	5 (1, 10)	6 (2, 13)	6 (2, 13)
	n_unique	10 (6, 16)	4 (1, 10)	4 (1, 9)	5 (2, 12)	5 (2, 11)
	post_p	NA (NA, NA)	0.48 (0.24, 0.78)	0.44 (0.23, 0.77)	0.46 (0.22, 0.83)	0.48 (0.21, 0.8)
	rate	0.113 (0.074, 0.188)	0.124 (0.07, 0.334)	0.13 (0.069, 0.366)	0.125 (0.067, 0.27)	0.124 (0.072, 0.329)
+—	graduation	0	20	7	4	3
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	19 (14, 26)	8 (3, 17)	11 (5, 21)	9 (3, 18)	8 (3, 17)
	n_unique	18 (12, 24)	7 (3, 16)	10 (4, 19)	8 (2, 16)	7 (2, 16)
	post_p	NA (NA, NA)	0.44 (0.18, 0.81)	0.49 (0.18, 0.85)	0.44 (0.18, 0.82)	0.46 (0.18, 0.81)
	rate	0.114 (0.078, 0.157)	0.128 (0.08, 0.254)	0.116 (0.077, 0.229)	0.125 (0.079, 0.299)	0.122 (0.075, 0.303)
+–+	graduation	0	47	50	33	34
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	15 (10, 21)	7 (2, 15)	8 (3, 16)	7 (2, 15)	7 (2, 13)
	n_unique	14 (9, 20)	6 (2, 14)	7 (3, 14)	6 (2, 13)	6 (2, 12)
	post_p	NA (NA, NA)	0.46 (0.2, 0.82)	0.44 (0.18, 0.84)	0.45 (0.2, 0.79)	0.44 (0.21, 0.83)
	rate	0.113 (0.076, 0.165)	0.126 (0.075, 0.323)	0.122 (0.074, 0.289)	0.126 (0.072, 0.318)	0.125 (0.071, 0.33)
+-+-	graduation	0	58	43	32	30
	futility	0	0	0	0	0
	max_n	0	1	11	7	12
	n	15 (10, 21)	7 (2, 14)	8 (3, 16)	6 (2, 14)	7 (3, 15)
	n_unique	14 (9, 20)	6 (2, 13)	7 (3, 14)	6 (2, 13)	6 (2, 13)
	post_p	NA (NA, NA)	0.48 (0.21, 0.83)	0.46 (0.18, 0.82)	0.44 (0.2, 0.81)	0.49 (0.21, 0.85)
	rate	0.116 (0.082, 0.17)	0.124 (0.072, 0.278)	0.128 (0.076, 0.25)	0.133 (0.073, 0.346)	0.12 (0.071, 0.276)
+-++	graduation	0	83	72	54	58
	futility	0	0	0	0	0
	max_n	0	1	10	7	11
	n	15 (10, 22)	6 (2, 14)	8 (3, 16)	7 (3, 15)	7 (2, 15)
	n_unique	14 (9, 20)	6 (2, 12)	7 (3, 15)	6 (2, 13)	6 (2, 14)
	post_p	NA (NA, NA)	0.41 (0.2, 0.81)	0.45 (0.19, 0.82)	0.47 (0.18, 0.83)	0.46 (0.2, 0.83)
	rate	0.112 (0.078, 0.166)	0.131 (0.074, 0.331)	0.126 (0.076, 0.249)	0.121 (0.073, 0.278)	0.124 (0.075, 0.319)
++–	graduation	0	44	36	30	30
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 16)	5 (2, 10)	5 (2, 11)	6 (2, 12)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 9)	4 (2, 10)	6 (2, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.46 (0.22, 0.8)	0.44 (0.21, 0.76)	0.44 (0.19, 0.8)	0.45 (0.21, 0.79)
	rate	0.112 (0.072, 0.178)	0.126 (0.066, 0.344)	0.137 (0.071, 0.356)	0.129 (0.072, 0.308)	0.132 (0.078, 0.3)
++-+	graduation	0	69	70	52	55
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 16)	5 (2, 10)	5 (2, 11)	6 (2, 12)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 9)	5 (1, 10)	5 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.48 (0.24, 0.79)	0.47 (0.23, 0.79)	0.45 (0.2, 0.79)	0.47 (0.2, 0.8)
	rate	0.117 (0.072, 0.176)	0.123 (0.069, 0.289)	0.127 (0.07, 0.336)	0.133 (0.07, 0.344)	0.124 (0.07, 0.317)
+++-	graduation	0	79	62	54	53
	futility	0	0	0	0	0
	max_n	0	1	11	7	12
	n	11 (7, 16)	5 (1, 11)	5 (2, 11)	6 (2, 12)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 10)	4 (1, 10)	6 (2, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.5 (0.23, 0.79)	0.44 (0.24, 0.82)	0.45 (0.21, 0.8)	0.47 (0.22, 0.81)
	rate	0.115 (0.075, 0.189)	0.121 (0.065, 0.328)	0.131 (0.063, 0.34)	0.131 (0.073, 0.321)	0.124 (0.075, 0.283)
++++	graduation	0	102	89	72	76
	futility	0	0	0	0	0
	max_n	0	1	10	7	11
	n	12 (7, 17)	5 (1, 10)	5 (1, 11)	6 (2, 12)	6 (2, 13)
	n_unique	10 (6, 16)	4 (1, 9)	5 (1, 10)	5 (2, 11)	5 (2, 12)
	post_p	NA (NA, NA)	0.45 (0.22, 0.78)	0.46 (0.23, 0.8)	0.46 (0.2, 0.8)	0.46 (0.21, 0.82)
	rate	0.111 (0.075, 0.171)	0.134 (0.07, 0.35)	0.124 (0.066, 0.345)	0.126 (0.073, 0.304)	0.125 (0.072, 0.328)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	9	5	3	2
	time_stop	4 (4, 5)	7 (4, 9)	5 (5, 11)	11 (9, 13)
	n_trt	30 (26, 31)	33 (31, 47)	25 (25, 67)	70 (56, 85)
	n_control	50 (36, 62)	67 (51, 103)	57 (55, 114)	111 (98, 124)
	post_p	0.9 (0.86, 0.94)	0.97 (0.97, 0.99)	0.96 (0.92, 0.99)	0.94 (0.9, 0.99)
	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	1.5 (1.1, 1.9)
TP53- & AR-	count	53	37	23	31
	time_stop	10 (6, 20)	13 (10, 26)	12 (10, 19)	17 (10, 27)
	n_trt	31 (25, 56)	34 (26, 73)	30 (25, 60)	37 (25, 71)
	n_control	39 (28, 83)	55 (40, 111)	55 (36, 87)	69 (41, 112)
	post_p	0.91 (0.86, 0.95)	0.94 (0.88, 0.98)	0.92 (0.86, 0.98)	0.94 (0.88, 0.99)
	order	1 (1, 1)	1 (1, 1.4)	1 (1, 1.8)	1 (1, 2)
TP53+	count	13	5	2	5
	time_stop	11 (8, 14)	12 (9, 16)	12 (11, 12)	11 (8, 24)
	n_trt	34 (27, 42)	43 (25, 49)	32 (31, 34)	28 (26, 85)
	n_control	53 (35, 62)	51 (37, 67)	43 (41, 45)	45 (36, 113)
	post_p	0.96 (0.88, 0.98)	0.95 (0.91, 0.97)	0.96 (0.94, 0.98)	0.95 (0.9, 1)
	order	1 (1, 1)	1 (1, 1)	1.5 (1.1, 1.9)	1 (1, 1)
DRD+	count	6	1	3	1
	time_stop	18 (16, 24)	21 (21, 21)	11 (9, 13)	11 (11, 11)
	n_trt	30 (26, 42)	29 (29, 29)	25 (25, 27)	26 (26, 26)
	n_control	46 (36, 66)	54 (54, 54)	36 (20, 38)	39 (39, 39)
	post_p	0.98 (0.93, 1)	0.99 (0.99, 0.99)	0.99 (0.95, 0.99)	0.96 (0.96, 0.96)
	order	1 (1, 1.5)	1 (1, 1)	1 (1, 1.8)	1 (1, 1)
TEfus+	count	5	5	1	6
	time_stop	15 (10, 20)	15 (9, 22)	9 (9, 9)	12 (10, 14)
	n_trt	26 (25, 39)	28 (25, 57)	27 (27, 27)	33 (28, 37)
	n_control	56 (41, 67)	52 (40, 93)	27 (27, 27)	46 (36, 52)
	post_p	0.95 (0.94, 0.98)	0.96 (0.96, 0.98)	1 (1, 1)	0.96 (0.86, 0.98)
	order	1 (1, 2.6)	1 (1, 1.6)	1 (1, 1)	1 (1, 2)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	11	2	1	1
	time_stop	5 (4, 6)	5 (5, 5)	8 (8, 8)	8 (8, 8)
	n_trt	33 (28, 44)	30 (28, 32)	34 (34, 34)	38 (38, 38)
	n_control	47 (39, 65)	54 (53, 54)	74 (74, 74)	70 (70, 70)
	post_p	0.1 (0.02, 0.27)	0.15 (0.09, 0.21)	0.02 (0.02, 0.02)	0.04 (0.04, 0.04)
	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	1 (1, 1)
TP53- & AR-	count	132	121	134	125
	time_stop	16 (8, 30)	21 (12, 32)	22 (13, 33)	23 (13, 34)
	n_trt	36 (26, 71)	32 (26, 78)	38 (25, 87)	37 (25, 83)
	n_control	70 (31, 139)	95 (53, 157)	101 (55, 161)	102 (57, 168)
	post_p	0.18 (0.07, 0.28)	0.14 (0.04, 0.28)	0.15 (0.04, 0.26)	0.14 (0.04, 0.26)
	order	1 (1, 3)	1 (1, 3)	2 (1, 3)	2 (1, 3)
TP53+	count	26	31	26	22
	time_stop	19 (9, 26)	19 (10, 34)	22 (14, 32)	22 (16, 34)
	n_trt	40 (25, 62)	42 (29, 83)	47 (30, 72)	45 (33, 62)
	n_control	84 (40, 130)	92 (38, 172)	108 (54, 159)	111 (73, 175)
	post_p	0.07 (0.01, 0.19)	0.04 (0.01, 0.13)	0.05 (0.01, 0.16)	0.05 (0, 0.17)
	order	1 (1, 2.5)	2 (1, 4)	2 (1, 4)	2 (1, 3)
DRD+	count	18	28	24	26
	time_stop	27 (20, 34)	30 (21, 34)	21 (11, 30)	21 (13, 32)
	n_trt	30 (25, 42)	34 (26, 46)	34 (25, 44)	33 (26, 46)
	n_control	76 (41, 97)	82 (59, 110)	60 (24, 87)	57 (34, 86)
	post_p	0.07 (0.04, 0.26)	0.05 (0.03, 0.22)	0.05 (0.02, 0.25)	0.05 (0.01, 0.12)
	order	2 (1, 4)	2 (1, 5)	2 (1, 3.7)	2 (1, 3)
TEfus+	count	23	38	28	25
	time_stop	21 (13, 33)	22 (11, 34)	23 (14, 31)	23 (16, 35)
	n_trt	35 (26, 48)	42 (27, 72)	38 (26, 51)	44 (31, 72)
	n_control	83 (48, 134)	90 (36, 136)	86 (49, 141)	83 (53, 128)
	post_p	0.08 (0, 0.18)	0.09 (0.01, 0.17)	0.05 (0.01, 0.21)	0.06 (0.01, 0.14)
	order	2 (1, 3)	2 (1, 4)	2 (1, 4)	2 (1, 3.6)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	9	9	9	9	9	9	9	9	9	9	9	9	9	9	9	9
		time	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)
		n	14 (11, 16)	2 (1, 3)	7 (5, 8)	2 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	2 (0, 3)	1 (0, 3)	0 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.6 (0.54, 0.67)	0.54 (0.52, 0.56)	0.6 (0.53, 0.69)	0.54 (0.52, 0.6)	0.51 (0.51, 0.51)	0.53 (0.51, 0.6)	0.54 (0.54, 0.54)	NA (NA, NA)	0.56 (0.52, 0.58)	0.56 (0.51, 0.61)	0.53 (0.53, 0.53)	0.5 (0.5, 0.5)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.056 (0, 0.092)	0 (0, 0.046)	0 (0, 0.08)	0 (0, 0.055)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0.036)	0 (0, 0.126)	0.261 (0.125, 0.396)	0.124 (0.025, 0.224)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)
	Taxel_therapies	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
		time	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)	7 (4, 9)
		n	8 (3, 12)	2 (0, 4)	5 (3, 9)	8 (6, 9)	1 (0, 2)	1 (0, 3)	0 (0, 0)	0 (0, 1)	4 (0, 5)	2 (1, 3)	2 (0, 3)	2 (1, 3)	1 (0, 2)	0 (0, 4)	1 (0, 2)	1 (0, 1)
		post_p	0.69 (0.54, 0.73)	0.56 (0.52, 0.59)	0.56 (0.54, 0.72)	0.66 (0.5, 0.73)	0.63 (0.56, 0.7)	0.54 (0.53, 0.58)	NA (NA, NA)	0.56 (0.54, 0.58)	0.57 (0.56, 0.57)	0.57 (0.56, 0.6)	0.58 (0.55, 0.64)	0.59 (0.51, 0.61)	0.55 (0.54, 0.58)	0.55 (0.55, 0.55)	0.53 (0.52, 0.55)	0.52 (0.52, 0.53)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.046 (0.014, 0.12)	0.03 (0, 0.143)	0 (0, 0.134)	0.072 (0.052, 0.108)	0 (0, 0)	0 (0, 0.114)	NA (NA, NA)	0 (0, 0)	0.02 (0, 0.051)	0 (0, 0.066)	0 (0, 0)	0 (0, 0.026)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Carboplatin	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)	5 (5, 11)
		n	3 (2, 13)	2 (0, 2)	3 (3, 14)	2 (0, 8)	3 (1, 5)	4 (2, 6)	2 (0, 4)	1 (0, 2)	0 (0, 2)	2 (0, 3)	1 (0, 2)	2 (1, 3)	3 (1, 3)	1 (0, 3)	3 (1, 5)	0 (0, 2)
		post_p	0.6 (0.57, 0.9)	0.57 (0.54, 0.59)	0.62 (0.6, 0.7)	0.52 (0.51, 0.53)	0.67 (0.55, 0.79)	0.7 (0.61, 0.75)	0.59 (0.52, 0.65)	0.57 (0.56, 0.59)	0.64 (0.64, 0.64)	0.53 (0.52, 0.54)	0.56 (0.54, 0.58)	0.56 (0.55, 0.59)	0.52 (0.5, 0.54)	0.53 (0.53, 0.54)	0.55 (0.53, 0.57)	0.69 (0.69, 0.69)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	0.042 (0.008, 0.076)	0 (0, 0.055)	0.048 (0.01, 0.087)	0.067 (0.013, 0.188)	0.069 (0.014, 0.104)	0.047 (0.009, 0.084)	0 (0, 0)	0 (0, 0)	0.046 (0.009, 0.084)	0 (0, 0)	0 (0, 0.084)	0 (0, 0)	0.054 (0.011, 0.096)	0.029 (0.006, 0.052)	0 (0, 0)
	Niraparib	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)
		n	19 (13, 25)	5 (3, 7)	7 (6, 8)	3 (2, 4)	2 (1, 2)	3 (2, 4)	4 (3, 5)	3 (2, 4)	2 (2, 2)	2 (2, 2)	3 (2, 4)	2 (1, 4)	2 (2, 3)	3 (2, 4)	4 (3, 6)	6 (4, 7)
		post_p	0.76 (0.7, 0.82)	0.54 (0.51, 0.57)	0.62 (0.61, 0.63)	0.62 (0.61, 0.62)	0.58 (0.54, 0.61)	0.65 (0.57, 0.72)	0.58 (0.53, 0.62)	0.58 (0.52, 0.65)	0.58 (0.53, 0.64)	0.58 (0.54, 0.63)	0.62 (0.54, 0.71)	0.65 (0.65, 0.65)	0.54 (0.52, 0.56)	0.61 (0.58, 0.64)	0.75 (0.69, 0.82)	0.6 (0.59, 0.6)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.071 (0.053, 0.089)	0.089 (0.059, 0.118)	0.086 (0.08, 0.092)	0.036 (0.007, 0.065)	0.026 (0.005, 0.046)	0 (0, 0)	0.058 (0.012, 0.105)	0.125 (0.075, 0.174)	0.116 (0.023, 0.209)	0.067 (0.013, 0.12)	0.107 (0.058, 0.157)	0.037 (0.037, 0.037)	0.186 (0.121, 0.252)	0.088 (0.018, 0.159)	0.045 (0.009, 0.081)	0.08 (0.016, 0.145)
TP53- & AR-	Hormone_therapies	count	53	53			53	53
		time	10 (6, 20)	10 (6, 20)			10 (6, 20)	10 (6, 20)
		n	25 (19, 39)	4 (2, 9)			2 (0, 5)	2 (0, 5)
		post_p	0.8 (0.71, 0.93)	0.59 (0.51, 0.77)			0.6 (0.53, 0.73)	0.57 (0.53, 0.75)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.082 (0.046, 0.106)	0.084 (0, 0.133)			0 (0, 0.142)	0 (0, 0.119)
	Taxel_therapies	count	37	37			37	37
		time	13 (10, 26)	13 (10, 26)			13 (10, 26)	13 (10, 26)
		n	22 (17, 45)	5 (2, 12)			3 (0, 11)	4 (1, 9)
		post_p	0.83 (0.73, 0.94)	0.64 (0.53, 0.82)			0.65 (0.51, 0.76)	0.67 (0.54, 0.82)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.079 (0.047, 0.1)	0.073 (0, 0.122)			0.067 (0, 0.127)	0.071 (0, 0.1)
	Carboplatin	count	23	23			23	23
		time	12 (10, 19)	12 (10, 19)			12 (10, 19)	12 (10, 19)
		n	20 (12, 46)	3 (1, 7)			4 (2, 10)	4 (2, 11)
		post_p	0.83 (0.72, 0.93)	0.59 (0.51, 0.73)			0.58 (0.52, 0.85)	0.7 (0.53, 0.84)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.068 (0.037, 0.098)	0.031 (0, 0.11)			0.078 (0.005, 0.122)	0.047 (0.003, 0.122)
	Niraparib	count	31	31			31	31
		time	17 (10, 27)	17 (10, 27)			17 (10, 27)	17 (10, 27)
		n	24 (13, 45)	4 (1, 8)			5 (2, 13)	5 (2, 14)
		post_p	0.86 (0.72, 0.94)	0.62 (0.52, 0.85)			0.65 (0.54, 0.84)	0.68 (0.52, 0.8)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.08 (0.05, 0.091)	0.057 (0, 0.1)			0.082 (0, 0.119)	0.07 (0, 0.127)
TP53+	Hormone_therapies	count			13	13			13	13			13	13			13	13
		time			11 (8, 14)	11 (8, 14)			11 (8, 14)	11 (8, 14)			11 (8, 14)	11 (8, 14)			11 (8, 14)	11 (8, 14)
		n			15 (11, 25)	7 (3, 10)			1 (0, 2)	1 (0, 3)			2 (1, 5)	3 (0, 4)			1 (0, 4)	1 (0, 3)
		post_p			0.8 (0.73, 0.91)	0.75 (0.62, 0.84)			0.6 (0.52, 0.65)	0.56 (0.53, 0.67)			0.56 (0.52, 0.64)	0.59 (0.51, 0.74)			0.56 (0.53, 0.69)	0.57 (0.53, 0.66)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.069 (0.04, 0.084)	0.044 (0, 0.089)			0 (0, 0.094)	0 (0, 0)			0.059 (0, 0.134)	0.071 (0, 0.181)			0 (0, 0.08)	0 (0, 0.104)
	Taxel_therapies	count			5	5			5	5			5	5			5	5
		time			12 (9, 16)	12 (9, 16)			12 (9, 16)	12 (9, 16)			12 (9, 16)	12 (9, 16)			12 (9, 16)	12 (9, 16)
		n			13 (8, 16)	11 (7, 17)			3 (1, 5)	1 (0, 2)			2 (1, 5)	4 (1, 6)			1 (0, 3)	2 (0, 5)
		post_p			0.8 (0.6, 0.83)	0.78 (0.65, 0.86)			0.63 (0.55, 0.75)	0.53 (0.51, 0.55)			0.55 (0.51, 0.66)	0.55 (0.51, 0.68)			0.56 (0.56, 0.59)	0.53 (0.52, 0.64)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.054 (0.044, 0.077)	0.072 (0.064, 0.09)			0.028 (0, 0.079)	0 (0, 0.058)			0.048 (0, 0.122)	0.064 (0.015, 0.083)			0 (0, 0.071)	0.046 (0, 0.113)
	Carboplatin	count			2	2			2	2			2	2			2	2
		time			12 (11, 12)	12 (11, 12)			12 (11, 12)	12 (11, 12)			12 (11, 12)	12 (11, 12)			12 (11, 12)	12 (11, 12)
		n			10 (6, 14)	5 (3, 7)			4 (4, 5)	0 (0, 1)			3 (3, 3)	4 (3, 5)			4 (3, 5)	2 (1, 2)
		post_p			0.66 (0.54, 0.78)	0.77 (0.71, 0.82)			0.67 (0.62, 0.72)	0.53 (0.53, 0.53)			0.62 (0.58, 0.66)	0.55 (0.53, 0.57)			0.63 (0.57, 0.69)	0.6 (0.53, 0.67)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.068 (0.065, 0.07)	0.016 (0.003, 0.029)			0.063 (0.045, 0.082)	0 (0, 0)			0.044 (0.009, 0.079)	0.08 (0.074, 0.086)			0.06 (0.055, 0.065)	0 (0, 0)
	Niraparib	count			5	5			5	5			5	5			5	5
		time			11 (8, 24)	11 (8, 24)			11 (8, 24)	11 (8, 24)			11 (8, 24)	11 (8, 24)			11 (8, 24)	11 (8, 24)
		n			13 (6, 31)	5 (2, 15)			3 (3, 4)	4 (1, 7)			2 (1, 6)	3 (1, 9)			3 (1, 6)	5 (3, 8)
		post_p			0.8 (0.75, 0.95)	0.55 (0.53, 0.72)			0.56 (0.56, 0.63)	0.56 (0.53, 0.67)			0.6 (0.51, 0.84)	0.55 (0.52, 0.75)			0.58 (0.55, 0.74)	0.63 (0.56, 0.75)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.045 (0, 0.076)	0.09 (0.029, 0.11)			0.072 (0.024, 0.112)	0.046 (0, 0.106)			0 (0, 0.058)	0.096 (0.027, 0.13)			0 (0, 0.086)	0.062 (0.036, 0.082)
DRD+	Hormone_therapies	count					6	6	6	6					6	6	6	6
		time					18 (16, 24)	18 (16, 24)	18 (16, 24)	18 (16, 24)					18 (16, 24)	18 (16, 24)	18 (16, 24)	18 (16, 24)
		n					9 (5, 11)	6 (3, 10)	3 (1, 3)	4 (2, 6)					2 (2, 4)	3 (2, 4)	4 (0, 4)	4 (1, 6)
		post_p					0.78 (0.64, 0.89)	0.73 (0.57, 0.92)	0.64 (0.61, 0.73)	0.64 (0.56, 0.76)					0.53 (0.51, 0.59)	0.58 (0.52, 0.64)	0.56 (0.53, 0.65)	0.69 (0.58, 0.84)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.068 (0.039, 0.075)	0.068 (0.026, 0.127)	0.047 (0, 0.058)	0.04 (0, 0.107)					0.085 (0.038, 0.104)	0 (0, 0.061)	0.051 (0.017, 0.144)	0.011 (0, 0.05)
	Taxel_therapies	count					1	1	1	1					1	1	1	1
		time					21 (21, 21)	21 (21, 21)	21 (21, 21)	21 (21, 21)					21 (21, 21)	21 (21, 21)	21 (21, 21)	21 (21, 21)
		n					5 (5, 5)	7 (7, 7)	5 (5, 5)	5 (5, 5)					1 (1, 1)	2 (2, 2)	4 (4, 4)	0 (0, 0)
		post_p					0.76 (0.76, 0.76)	0.79 (0.79, 0.79)	0.88 (0.88, 0.88)	0.82 (0.82, 0.82)					0.57 (0.57, 0.57)	0.75 (0.75, 0.75)	0.56 (0.56, 0.56)	NA (NA, NA)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.105 (0.105, 0.105)	0.085 (0.085, 0.085)	0.083 (0.083, 0.083)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0.046 (0.046, 0.046)	NA (NA, NA)
	Carboplatin	count					3	3	3	3					3	3	3	3
		time					11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)					11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)
		n					4 (4, 6)	5 (2, 5)	4 (3, 5)	2 (2, 3)					3 (1, 4)	3 (2, 5)	4 (2, 5)	2 (0, 2)
		post_p					0.69 (0.64, 0.8)	0.7 (0.64, 0.83)	0.53 (0.52, 0.64)	0.55 (0.53, 0.59)					0.55 (0.55, 0.64)	0.58 (0.55, 0.59)	0.57 (0.52, 0.58)	0.6 (0.54, 0.67)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.06 (0.045, 0.066)	0.037 (0.007, 0.098)	0.071 (0.07, 0.089)	0 (0, 0.074)					0.133 (0.027, 0.197)	0.038 (0.008, 0.093)	0.058 (0.047, 0.208)	0 (0, 0)
	Niraparib	count					1	1	1	1					1	1	1	1
		time					11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)					11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)
		n					3 (3, 3)	3 (3, 3)	4 (4, 4)	4 (4, 4)					3 (3, 3)	2 (2, 2)	5 (5, 5)	2 (2, 2)
		post_p					0.65 (0.65, 0.65)	0.52 (0.52, 0.52)	0.7 (0.7, 0.7)	0.58 (0.58, 0.58)					0.55 (0.55, 0.55)	0.56 (0.56, 0.56)	0.59 (0.59, 0.59)	0.55 (0.55, 0.55)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0 (0, 0)	0.078 (0.078, 0.078)	0.097 (0.097, 0.097)	0.11 (0.11, 0.11)					0.155 (0.155, 0.155)	0 (0, 0)	0.033 (0.033, 0.033)	0 (0, 0)
TEfus+	Hormone_therapies	count		5		5		5		5		5		5		5		5
		time		15 (10, 20)		15 (10, 20)		15 (10, 20)		15 (10, 20)		15 (10, 20)		15 (10, 20)		15 (10, 20)		15 (10, 20)
		n		2 (2, 6)		7 (5, 15)		1 (1, 5)		3 (1, 5)		3 (2, 7)		4 (0, 8)		2 (2, 3)		1 (0, 3)
		post_p		0.61 (0.54, 0.76)		0.75 (0.71, 0.81)		0.63 (0.56, 0.74)		0.57 (0.52, 0.62)		0.66 (0.6, 0.81)		0.66 (0.56, 0.82)		0.56 (0.52, 0.67)		0.6 (0.58, 0.65)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.065 (0.017, 0.089)		0.073 (0.064, 0.074)		0 (0, 0.097)		0.056 (0, 0.134)		0.059 (0.023, 0.105)		0.053 (0.013, 0.084)		0.075 (0, 0.205)		0 (0, 0.057)
	Taxel_therapies	count		5		5		5		5		5		5		5		5
		time		15 (9, 22)		15 (9, 22)		15 (9, 22)		15 (9, 22)		15 (9, 22)		15 (9, 22)		15 (9, 22)		15 (9, 22)
		n		5 (4, 12)		13 (11, 14)		5 (2, 6)		1 (0, 3)		1 (0, 9)		5 (2, 11)		2 (0, 4)		0 (0, 1)
		post_p		0.71 (0.58, 0.79)		0.77 (0.72, 0.87)		0.62 (0.55, 0.69)		0.57 (0.52, 0.65)		0.58 (0.53, 0.78)		0.87 (0.56, 0.9)		0.54 (0.51, 0.65)		0.63 (0.63, 0.63)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.067 (0.011, 0.089)		0.063 (0.041, 0.097)		0 (0, 0.091)		0.045 (0, 0.1)		0.08 (0.016, 0.115)		0.071 (0.02, 0.124)		0.04 (0, 0.115)		0 (0, 0)
	Carboplatin	count		1		1		1		1		1		1		1		1
		time		9 (9, 9)		9 (9, 9)		9 (9, 9)		9 (9, 9)		9 (9, 9)		9 (9, 9)		9 (9, 9)		9 (9, 9)
		n		4 (4, 4)		4 (4, 4)		8 (8, 8)		2 (2, 2)		3 (3, 3)		2 (2, 2)		2 (2, 2)		2 (2, 2)
		post_p		0.76 (0.76, 0.76)		0.76 (0.76, 0.76)		0.78 (0.78, 0.78)		0.56 (0.56, 0.56)		0.55 (0.55, 0.55)		0.57 (0.57, 0.57)		0.66 (0.66, 0.66)		0.52 (0.52, 0.52)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.086 (0.086, 0.086)		0 (0, 0)		0 (0, 0)		0 (0, 0)
	Niraparib	count		6		6		6		6		6		6		6		6
		time		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)
		n		2 (1, 8)		5 (4, 11)		6 (4, 10)		3 (1, 4)		4 (2, 4)		3 (2, 7)		4 (1, 4)		2 (2, 5)
		post_p		0.6 (0.55, 0.73)		0.63 (0.56, 0.75)		0.67 (0.52, 0.92)		0.52 (0.51, 0.56)		0.56 (0.52, 0.66)		0.62 (0.59, 0.76)		0.69 (0.62, 0.71)		0.56 (0.52, 0.73)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0.061)		0.077 (0.071, 0.094)		0.088 (0.07, 0.149)		0.015 (0, 0.097)		0.058 (0, 0.138)		0 (0, 0.058)		0.074 (0.017, 0.092)		0.061 (0, 0.236)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11
		time	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)
		n	14 (12, 20)	3 (2, 3)	8 (6, 13)	3 (2, 5)	0 (0, 1)	0 (0, 1)	0 (0, 2)	0 (0, 1)	2 (0, 3)	0 (0, 2)	1 (0, 3)	0 (0, 5)	0 (0, 1)	0 (0, 2)	0 (0, 1)	0 (0, 0)
		post_p	0.37 (0.13, 0.48)	0.47 (0.42, 0.49)	0.39 (0.37, 0.48)	0.44 (0.34, 0.48)	0.45 (0.42, 0.49)	0.45 (0.45, 0.45)	0.48 (0.48, 0.48)	0.3 (0.3, 0.3)	0.44 (0.27, 0.47)	0.4 (0.28, 0.41)	0.45 (0.37, 0.48)	0.44 (0.35, 0.46)	0.44 (0.42, 0.47)	0.45 (0.27, 0.47)	0.37 (0.31, 0.43)	0.48 (0.48, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.193 (0.087, 0.287)	0.229 (0.139, 0.392)	0.158 (0.084, 0.274)	0.216 (0, 0.285)	0.691 (0.041, 34.89)	1.121 (0.36, 1.882)	0 (0, 0.087)	4.95 (1.153, 8.747)	0.221 (0.087, 0.696)	0.586 (0.387, 0.638)	0.165 (0, 0.289)	0.235 (0.178, 0.486)	0 (0, 0.31)	0.266 (0, 0.639)	0 (0, 0.157)	0 (0, 0)
	Taxel_therapies	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
		n	4 (3, 5)	1 (0, 2)	8 (8, 8)	6 (4, 8)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	4 (2, 6)	1 (0, 2)	2 (1, 2)	2 (1, 4)	0 (0, 1)	1 (0, 2)	0 (0, 0)	0 (0, 1)
		post_p	0.46 (0.44, 0.47)	0.47 (0.47, 0.47)	0.35 (0.27, 0.42)	0.47 (0.44, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.49 (0.49, 0.49)	0.46 (0.45, 0.46)	0.36 (0.36, 0.36)	0.44 (0.44, 0.44)	0.47 (0.47, 0.47)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	0.44 (0.44, 0.44)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.194 (0.194, 0.194)	0.189 (0.189, 0.189)	0.187 (0.164, 0.209)	0.193 (0.168, 0.218)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.17 (0.142, 0.198)	1.804 (1.804, 1.804)	0.158 (0.032, 0.284)	0.054 (0.011, 0.097)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	2.366 (2.366, 2.366)
	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)
		n	12 (12, 12)	0 (0, 0)	4 (4, 4)	2 (2, 2)	4 (4, 4)	4 (4, 4)	0 (0, 0)	3 (3, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	4 (4, 4)	0 (0, 0)	0 (0, 0)
		post_p	0.32 (0.32, 0.32)	NA (NA, NA)	0.47 (0.47, 0.47)	0.33 (0.33, 0.33)	0.45 (0.45, 0.45)	0.48 (0.48, 0.48)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.46 (0.46, 0.46)	0.38 (0.38, 0.38)	NA (NA, NA)	NA (NA, NA)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.144 (0.144, 0.144)	NA (NA, NA)	0.1 (0.1, 0.1)	5.488 (5.488, 5.488)	0.148 (0.148, 0.148)	0.094 (0.094, 0.094)	NA (NA, NA)	0.117 (0.117, 0.117)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.288 (0.288, 0.288)	0.293 (0.293, 0.293)	NA (NA, NA)	NA (NA, NA)
	Niraparib	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)
		n	3 (3, 3)	0 (0, 0)	11 (11, 11)	6 (6, 6)	4 (4, 4)	5 (5, 5)	1 (1, 1)	2 (2, 2)	1 (1, 1)	1 (1, 1)	0 (0, 0)	1 (1, 1)	1 (1, 1)	2 (2, 2)	0 (0, 0)	0 (0, 0)
		post_p	0.49 (0.49, 0.49)	NA (NA, NA)	0.47 (0.47, 0.47)	0.46 (0.46, 0.46)	0.46 (0.46, 0.46)	0.33 (0.33, 0.33)	0.46 (0.46, 0.46)	0.4 (0.4, 0.4)	0.38 (0.38, 0.38)	0.41 (0.41, 0.41)	NA (NA, NA)	0.43 (0.43, 0.43)	0.5 (0.5, 0.5)	0.41 (0.41, 0.41)	NA (NA, NA)	NA (NA, NA)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.156 (0.156, 0.156)	NA (NA, NA)	0.109 (0.109, 0.109)	0.135 (0.135, 0.135)	0.157 (0.157, 0.157)	0.246 (0.246, 0.246)	0.224 (0.224, 0.224)	1.23 (1.23, 1.23)	0.505 (0.505, 0.505)	1.058 (1.058, 1.058)	NA (NA, NA)	0.356 (0.356, 0.356)	0.317 (0.317, 0.317)	0.195 (0.195, 0.195)	NA (NA, NA)	NA (NA, NA)
TP53- & AR-	Hormone_therapies	count	132	132			132	132
		time	16 (8, 30)	16 (8, 30)			16 (8, 30)	16 (8, 30)
		n	26 (17, 53)	5 (3, 10)			3 (1, 9)	3 (0, 8)
		post_p	0.32 (0.13, 0.47)	0.39 (0.21, 0.48)			0.4 (0.22, 0.48)	0.4 (0.23, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.125 (0.102, 0.17)	0.137 (0.088, 0.342)			0.178 (0.1, 0.539)	0.182 (0.11, 0.709)
	Taxel_therapies	count	121	121			121	121
		time	21 (12, 32)	21 (12, 32)			21 (12, 32)	21 (12, 32)
		n	17 (10, 59)	6 (3, 13)			4 (1, 12)	4 (1, 11)
		post_p	0.35 (0.1, 0.47)	0.36 (0.17, 0.48)			0.41 (0.2, 0.49)	0.38 (0.22, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.131 (0.106, 0.207)	0.164 (0.105, 0.363)			0.161 (0.109, 0.379)	0.169 (0.111, 0.397)
	Carboplatin	count	134	134			134	134
		time	22 (13, 33)	22 (13, 33)			22 (13, 33)	22 (13, 33)
		n	20 (8, 57)	5 (2, 13)			6 (3, 12)	6 (3, 13)
		post_p	0.35 (0.1, 0.47)	0.39 (0.22, 0.48)			0.36 (0.18, 0.48)	0.36 (0.18, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.133 (0.103, 0.201)	0.159 (0.113, 0.412)			0.156 (0.104, 0.388)	0.147 (0.097, 0.326)
	Niraparib	count	125	125			125	125
		time	23 (13, 34)	23 (13, 34)			23 (13, 34)	23 (13, 34)
		n	18 (7, 53)	5 (2, 13)			6 (3, 15)	7 (3, 15)
		post_p	0.33 (0.11, 0.47)	0.37 (0.19, 0.49)			0.36 (0.2, 0.48)	0.36 (0.17, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.134 (0.108, 0.232)	0.157 (0.105, 0.398)			0.148 (0.102, 0.299)	0.151 (0.112, 0.334)
TP53+	Hormone_therapies	count			26	26			26	26			26	26			26	26
		time			19 (9, 26)	19 (9, 26)			19 (9, 26)	19 (9, 26)			19 (9, 26)	19 (9, 26)			19 (9, 26)	19 (9, 26)
		n			14 (8, 28)	8 (4, 15)			3 (0, 5)	2 (0, 6)			4 (1, 7)	3 (0, 6)			2 (0, 5)	1 (0, 4)
		post_p			0.36 (0.14, 0.42)	0.3 (0.12, 0.46)			0.44 (0.25, 0.5)	0.42 (0.33, 0.49)			0.45 (0.26, 0.49)	0.35 (0.24, 0.46)			0.39 (0.32, 0.48)	0.42 (0.3, 0.47)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.136 (0.096, 0.194)	0.153 (0.098, 0.29)			0.208 (0.1, 0.475)	0.204 (0.126, 0.771)			0.157 (0.088, 0.318)	0.211 (0.102, 0.446)			0.199 (0.116, 1.882)	0.206 (0.108, 0.441)
	Taxel_therapies	count			31	31			31	31			31	31			31	31
		time			19 (10, 34)	19 (10, 34)			19 (10, 34)	19 (10, 34)			19 (10, 34)	19 (10, 34)			19 (10, 34)	19 (10, 34)
		n			11 (6, 20)	12 (7, 22)			2 (0, 6)	3 (1, 6)			6 (3, 11)	6 (2, 9)			3 (1, 9)	2 (0, 7)
		post_p			0.33 (0.06, 0.44)	0.32 (0.13, 0.47)			0.37 (0.2, 0.46)	0.42 (0.33, 0.48)			0.38 (0.16, 0.49)	0.36 (0.18, 0.47)			0.38 (0.27, 0.49)	0.42 (0.24, 0.48)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.14 (0.099, 0.205)	0.14 (0.094, 0.224)			0.248 (0.102, 1.601)	0.173 (0.117, 0.877)			0.161 (0.1, 0.243)	0.144 (0.091, 0.477)			0.223 (0.107, 0.46)	0.192 (0.095, 0.65)
	Carboplatin	count			26	26			26	26			26	26			26	26
		time			22 (14, 32)	22 (14, 32)			22 (14, 32)	22 (14, 32)			22 (14, 32)	22 (14, 32)			22 (14, 32)	22 (14, 32)
		n			12 (5, 30)	8 (4, 16)			3 (1, 6)	4 (2, 9)			3 (2, 8)	4 (2, 8)			4 (2, 8)	4 (2, 6)
		post_p			0.31 (0.15, 0.45)	0.31 (0.15, 0.44)			0.39 (0.15, 0.47)	0.38 (0.19, 0.48)			0.39 (0.22, 0.48)	0.37 (0.23, 0.47)			0.41 (0.2, 0.49)	0.4 (0.23, 0.48)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.146 (0.1, 0.255)	0.18 (0.1, 0.336)			0.165 (0.089, 0.673)	0.175 (0.079, 0.709)			0.202 (0.112, 0.445)	0.204 (0.12, 0.366)			0.162 (0.107, 0.405)	0.185 (0.116, 0.44)
	Niraparib	count			22	22			22	22			22	22			22	22
		time			22 (16, 34)	22 (16, 34)			22 (16, 34)	22 (16, 34)			22 (16, 34)	22 (16, 34)			22 (16, 34)	22 (16, 34)
		n			9 (6, 22)	10 (4, 16)			4 (1, 6)	3 (2, 6)			4 (2, 7)	4 (1, 9)			4 (2, 8)	4 (1, 8)
		post_p			0.24 (0.09, 0.44)	0.38 (0.17, 0.46)			0.38 (0.21, 0.49)	0.33 (0.17, 0.48)			0.34 (0.2, 0.47)	0.32 (0.22, 0.46)			0.38 (0.23, 0.49)	0.4 (0.14, 0.48)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.173 (0.109, 0.366)	0.139 (0.114, 0.319)			0.186 (0.109, 0.324)	0.196 (0.107, 0.459)			0.154 (0.101, 0.415)	0.205 (0.128, 0.518)			0.17 (0.11, 0.355)	0.167 (0.093, 0.411)
DRD+	Hormone_therapies	count					18	18	18	18					18	18	18	18
		time					27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)					27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)
		n					5 (2, 10)	4 (2, 10)	4 (1, 5)	3 (1, 9)					4 (1, 6)	4 (1, 6)	4 (1, 6)	4 (1, 5)
		post_p					0.4 (0.22, 0.49)	0.38 (0.28, 0.48)	0.4 (0.33, 0.48)	0.42 (0.23, 0.5)					0.42 (0.28, 0.48)	0.41 (0.23, 0.48)	0.39 (0.27, 0.47)	0.32 (0.2, 0.47)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.159 (0.119, 0.343)	0.179 (0.121, 0.717)	0.158 (0.109, 0.369)	0.147 (0.097, 0.657)					0.171 (0.12, 0.286)	0.162 (0.116, 0.353)	0.134 (0.105, 0.354)	0.182 (0.123, 0.372)
	Taxel_therapies	count					28	28	28	28					28	28	28	28
		time					30 (21, 34)	30 (21, 34)	30 (21, 34)	30 (21, 34)					30 (21, 34)	30 (21, 34)	30 (21, 34)	30 (21, 34)
		n					6 (1, 11)	5 (2, 11)	3 (1, 6)	2 (0, 5)					3 (1, 7)	3 (1, 6)	4 (2, 8)	4 (2, 7)
		post_p					0.39 (0.23, 0.48)	0.28 (0.14, 0.49)	0.37 (0.28, 0.47)	0.38 (0.27, 0.46)					0.37 (0.23, 0.46)	0.41 (0.24, 0.48)	0.44 (0.29, 0.49)	0.36 (0.26, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.147 (0.113, 0.258)	0.204 (0.114, 0.419)	0.166 (0.115, 0.782)	0.173 (0.12, 0.427)					0.206 (0.121, 0.504)	0.168 (0.093, 0.623)	0.16 (0.105, 0.336)	0.153 (0.105, 0.343)
	Carboplatin	count					24	24	24	24					24	24	24	24
		time					21 (11, 30)	21 (11, 30)	21 (11, 30)	21 (11, 30)					21 (11, 30)	21 (11, 30)	21 (11, 30)	21 (11, 30)
		n					4 (2, 9)	6 (2, 11)	3 (1, 6)	4 (1, 6)					4 (1, 7)	4 (1, 6)	4 (2, 7)	4 (1, 7)
		post_p					0.39 (0.18, 0.49)	0.37 (0.18, 0.47)	0.41 (0.18, 0.45)	0.37 (0.21, 0.49)					0.41 (0.25, 0.48)	0.42 (0.28, 0.49)	0.37 (0.23, 0.49)	0.38 (0.2, 0.49)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.186 (0.104, 0.433)	0.172 (0.108, 0.31)	0.165 (0.115, 0.435)	0.17 (0.075, 0.27)					0.157 (0.102, 0.389)	0.181 (0.115, 0.33)	0.152 (0.087, 0.415)	0.187 (0.109, 0.416)
	Niraparib	count					26	26	26	26					26	26	26	26
		time					21 (13, 32)	21 (13, 32)	21 (13, 32)	21 (13, 32)					21 (13, 32)	21 (13, 32)	21 (13, 32)	21 (13, 32)
		n					5 (3, 10)	5 (3, 9)	4 (2, 10)	3 (1, 6)					3 (1, 8)	3 (1, 8)	4 (2, 7)	4 (1, 8)
		post_p					0.34 (0.17, 0.47)	0.38 (0.16, 0.48)	0.37 (0.15, 0.48)	0.39 (0.3, 0.46)					0.38 (0.26, 0.48)	0.38 (0.23, 0.48)	0.35 (0.23, 0.47)	0.36 (0.21, 0.47)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.157 (0.119, 0.361)	0.17 (0.105, 0.307)	0.187 (0.111, 0.358)	0.19 (0.118, 0.569)					0.187 (0.098, 0.488)	0.177 (0.117, 0.503)	0.181 (0.094, 0.519)	0.184 (0.108, 0.953)
TEfus+	Hormone_therapies	count		23		23		23		23		23		23		23		23
		time		21 (13, 33)		21 (13, 33)		21 (13, 33)		21 (13, 33)		21 (13, 33)		21 (13, 33)		21 (13, 33)		21 (13, 33)
		n		6 (3, 9)		10 (4, 16)		3 (0, 6)		3 (1, 8)		3 (2, 6)		3 (2, 8)		3 (1, 6)		2 (0, 5)
		post_p		0.36 (0.16, 0.44)		0.35 (0.22, 0.47)		0.4 (0.17, 0.46)		0.43 (0.25, 0.5)		0.38 (0.22, 0.46)		0.34 (0.19, 0.44)		0.41 (0.24, 0.48)		0.4 (0.24, 0.49)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.158 (0.108, 0.37)		0.142 (0.115, 0.259)		0.145 (0.109, 0.885)		0.17 (0.101, 0.445)		0.198 (0.104, 0.558)		0.268 (0.12, 0.666)		0.149 (0.116, 0.58)		0.167 (0.13, 0.427)
	Taxel_therapies	count		38		38		38		38		38		38		38		38
		time		22 (11, 34)		22 (11, 34)		22 (11, 34)		22 (11, 34)		22 (11, 34)		22 (11, 34)		22 (11, 34)		22 (11, 34)
		n		6 (2, 14)		12 (7, 24)		3 (1, 8)		3 (0, 6)		5 (2, 10)		4 (2, 9)		2 (0, 6)		3 (1, 6)
		post_p		0.35 (0.14, 0.47)		0.35 (0.16, 0.45)		0.4 (0.17, 0.49)		0.42 (0.27, 0.49)		0.36 (0.25, 0.49)		0.34 (0.24, 0.46)		0.41 (0.28, 0.48)		0.4 (0.22, 0.49)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.167 (0.113, 0.477)		0.127 (0.085, 0.162)		0.155 (0.102, 0.662)		0.165 (0.096, 0.999)		0.156 (0.101, 0.357)		0.159 (0.098, 0.434)		0.163 (0.125, 0.432)		0.184 (0.115, 0.644)
	Carboplatin	count		28		28		28		28		28		28		28		28
		time		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)		23 (14, 31)
		n		4 (1, 10)		8 (4, 13)		6 (3, 9)		4 (2, 10)		4 (1, 5)		4 (1, 8)		4 (1, 6)		4 (3, 7)
		post_p		0.38 (0.23, 0.48)		0.36 (0.1, 0.49)		0.34 (0.23, 0.48)		0.42 (0.22, 0.49)		0.39 (0.26, 0.45)		0.42 (0.21, 0.48)		0.39 (0.26, 0.46)		0.36 (0.23, 0.45)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.167 (0.102, 0.384)		0.161 (0.089, 0.338)		0.165 (0.101, 0.475)		0.167 (0.08, 0.373)		0.181 (0.107, 0.336)		0.15 (0.092, 0.3)		0.218 (0.105, 0.414)		0.171 (0.108, 0.403)
	Niraparib	count		25		25		25		25		25		25		25		25
		time		23 (16, 35)		23 (16, 35)		23 (16, 35)		23 (16, 35)		23 (16, 35)		23 (16, 35)		23 (16, 35)		23 (16, 35)
		n		4 (2, 9)		7 (4, 23)		5 (3, 10)		4 (2, 8)		4 (1, 9)		5 (2, 12)		4 (1, 11)		3 (1, 9)
		post_p		0.33 (0.15, 0.47)		0.27 (0.14, 0.46)		0.31 (0.13, 0.46)		0.38 (0.21, 0.47)		0.4 (0.21, 0.48)		0.42 (0.26, 0.49)		0.4 (0.2, 0.49)		0.41 (0.22, 0.47)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.204 (0.122, 0.665)		0.151 (0.113, 0.257)		0.167 (0.117, 0.294)		0.153 (0.107, 0.351)		0.163 (0.094, 0.493)		0.157 (0.083, 0.322)		0.157 (0.101, 0.416)		0.158 (0.085, 0.452)