Setting description

Treatments equally effective across the biomarker signatures

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 9 5 3 2
TP53- & AR- 53 37 23 31
TP53+ 13 5 2 5
DRD+ 6 1 3 1
TEfus+ 5 5 1 6
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.018 0.010 0.006 0.004
TP53- & AR- 0.106 0.074 0.046 0.062
TP53+ 0.026 0.010 0.004 0.010
DRD+ 0.012 0.002 0.006 0.002
TEfus+ 0.010 0.010 0.002 0.012
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 11 2 1 1
TP53- & AR- 132 121 134 125
TP53+ 26 31 26 22
DRD+ 18 28 24 26
TEfus+ 23 38 28 25
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.022 0.004 0.002 0.002
TP53- & AR- 0.264 0.242 0.268 0.250
TP53+ 0.052 0.062 0.052 0.044
DRD+ 0.036 0.056 0.048 0.052
TEfus+ 0.046 0.076 0.056 0.050
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 20 15 19 18
TP53+ 1 11 7 12
DRD+ 0 0 0 0
TEfus+ 0 0 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.040 0.030 0.038 0.036
TP53+ 0.002 0.022 0.014 0.024
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.000


Errors & power

The overall error was 0.37.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.168             0.104             0.058             0.086 

The overall power was .
The corresponding power separate for the different treatments were:

NULL

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 9 5 3 2
futility 0 11 2 1 1
max_n 0 0 0 0 0
n 411 (377, 451) 185 (125, 252) 192 (137, 254) 193 (137, 257) 189 (135, 257)
n_unique 377 (345, 411) 170 (113, 235) 174 (125, 234) 176 (124, 239) 171 (121, 236)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 4 (4, 6) 5 (5, 8) 6 (5, 12) 9 (8, 12)
post_p NA (NA, NA) 0.49 (0.11, 0.87) 0.49 (0.08, 0.87) 0.47 (0.1, 0.88) 0.48 (0.09, 0.88)
rate 0.112 (0.104, 0.119) 0.113 (0.103, 0.125) 0.113 (0.102, 0.125) 0.113 (0.102, 0.125) 0.112 (0.101, 0.127)
TP53- & AR- graduation 0 53 37 23 31
futility 0 132 121 134 125
max_n 0 20 15 19 18
n 172 (149, 199) 69 (27, 135) 66 (28, 119) 68 (28, 128) 70 (27, 128)
n_unique 158 (137, 183) 63 (25, 127) 60 (25, 110) 63 (26, 120) 64 (25, 120)
time_trial 36 (36, 36) 36 (10, 36) 36 (16, 36) 36 (16, 36) 36 (18, 36)
time_stop NA (NA, NA) 15 (7, 29) 18 (11, 31) 21 (12, 33) 22 (12, 32)
post_p NA (NA, NA) 0.48 (0.1, 0.89) 0.45 (0.08, 0.88) 0.5 (0.08, 0.88) 0.48 (0.09, 0.9)
rate 0.112 (0.099, 0.125) 0.113 (0.095, 0.141) 0.114 (0.096, 0.146) 0.114 (0.096, 0.141) 0.114 (0.095, 0.143)
TP53+ graduation 0 13 5 2 5
futility 0 26 31 26 22
max_n 0 1 11 7 12
n 180 (158, 206) 85 (46, 118) 89 (55, 125) 89 (58, 124) 85 (57, 122)
n_unique 166 (143, 188) 77 (40, 108) 81 (49, 115) 81 (52, 114) 78 (51, 111)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 12 (9, 24) 16 (10, 34) 20 (13, 32) 21 (11, 33)
post_p NA (NA, NA) 0.48 (0.11, 0.86) 0.49 (0.09, 0.9) 0.49 (0.11, 0.85) 0.49 (0.09, 0.86)
rate 0.112 (0.1, 0.125) 0.112 (0.098, 0.136) 0.113 (0.098, 0.133) 0.113 (0.098, 0.133) 0.113 (0.098, 0.135)
DRD+ graduation 0 6 1 3 1
futility 0 18 28 24 26
max_n 0 0 0 0 0
n 110 (94, 125) 49 (29, 70) 52 (32, 71) 62 (44, 82) 61 (43, 81)
n_unique 99 (85, 116) 43 (25, 64) 47 (29, 65) 55 (39, 75) 56 (39, 73)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 24 (17, 33) 29 (21, 34) 20 (9, 29) 21 (12, 32)
post_p NA (NA, NA) 0.48 (0.13, 0.86) 0.48 (0.12, 0.83) 0.48 (0.12, 0.89) 0.48 (0.12, 0.86)
rate 0.112 (0.099, 0.128) 0.113 (0.093, 0.141) 0.114 (0.094, 0.143) 0.113 (0.096, 0.137) 0.114 (0.096, 0.139)
TEfus+ graduation 0 5 5 1 6
futility 0 23 38 28 25
max_n 0 0 0 0 0
n 150 (130, 169) 68 (38, 94) 77 (48, 105) 73 (48, 100) 72 (47, 100)
n_unique 136 (118, 155) 61 (34, 85) 71 (45, 95) 66 (42, 90) 66 (43, 91)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 20 (12, 33) 20 (10, 34) 22 (14, 30) 20 (13, 35)
post_p NA (NA, NA) 0.45 (0.1, 0.86) 0.48 (0.11, 0.86) 0.46 (0.1, 0.87) 0.46 (0.09, 0.86)
rate 0.111 (0.1, 0.125) 0.113 (0.096, 0.137) 0.113 (0.096, 0.136) 0.113 (0.097, 0.136) 0.114 (0.096, 0.137)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 203 165 161 158
futility 0 0 0 0 0
max_n 0 20 15 19 18
n 110 (92, 131) 38 (18, 98) 34 (11, 85) 36 (11, 88) 36 (11, 91)
n_unique 102 (84, 122) 35 (17, 94) 32 (9, 81) 34 (10, 84) 34 (9, 88)
post_p NA (NA, NA) 0.46 (0.1, 0.88) 0.44 (0.09, 0.88) 0.45 (0.1, 0.86) 0.45 (0.11, 0.9)
rate 0.112 (0.098, 0.13) 0.115 (0.095, 0.152) 0.116 (0.095, 0.194) 0.117 (0.094, 0.181) 0.116 (0.092, 0.172)
—+ graduation 0 214 188 171 177
futility 0 0 0 0 0
max_n 0 20 15 19 18
n 20 (15, 27) 7 (3, 19) 9 (3, 21) 8 (2, 19) 8 (2, 19)
n_unique 19 (13, 25) 7 (2, 17) 8 (3, 19) 7 (2, 18) 7 (2, 17)
post_p NA (NA, NA) 0.45 (0.17, 0.79) 0.44 (0.17, 0.84) 0.46 (0.21, 0.79) 0.45 (0.2, 0.83)
rate 0.112 (0.081, 0.155) 0.122 (0.077, 0.244) 0.12 (0.081, 0.268) 0.124 (0.081, 0.275) 0.121 (0.078, 0.29)
–+- graduation 0 58 43 32 30
futility 0 0 0 0 0
max_n 0 1 11 7 12
n 62 (49, 76) 24 (9, 55) 25 (7, 53) 27 (8, 56) 24 (7, 52)
n_unique 57 (44, 71) 23 (9, 52) 23 (6, 49) 25 (7, 52) 21 (6, 49)
post_p NA (NA, NA) 0.46 (0.12, 0.87) 0.43 (0.1, 0.88) 0.48 (0.13, 0.85) 0.41 (0.13, 0.86)
rate 0.112 (0.092, 0.137) 0.118 (0.092, 0.183) 0.122 (0.089, 0.214) 0.116 (0.089, 0.197) 0.122 (0.092, 0.22)
–++ graduation 0 83 72 54 58
futility 0 0 0 0 0
max_n 0 1 10 7 11
n 42 (32, 53) 15 (5, 36) 20 (8, 41) 15 (5, 35) 15 (5, 35)
n_unique 38 (28, 49) 13 (5, 33) 18 (7, 37) 14 (4, 32) 14 (4, 32)
post_p NA (NA, NA) 0.44 (0.13, 0.84) 0.47 (0.13, 0.85) 0.41 (0.12, 0.86) 0.42 (0.13, 0.82)
rate 0.11 (0.088, 0.139) 0.12 (0.087, 0.223) 0.116 (0.087, 0.195) 0.122 (0.085, 0.263) 0.12 (0.085, 0.253)
-+– graduation 0 217 182 171 172
futility 0 0 0 0 0
max_n 0 20 15 19 18
n 20 (14, 27) 7 (1, 18) 8 (2, 18) 9 (3, 20) 9 (4, 21)
n_unique 18 (13, 25) 6 (1, 17) 7 (2, 16) 8 (3, 19) 8 (3, 19)
post_p NA (NA, NA) 0.45 (0.19, 0.83) 0.47 (0.21, 0.79) 0.49 (0.18, 0.85) 0.44 (0.17, 0.83)
rate 0.113 (0.083, 0.159) 0.124 (0.075, 0.324) 0.124 (0.081, 0.272) 0.12 (0.076, 0.249) 0.125 (0.078, 0.237)
-+-+ graduation 0 228 201 180 188
futility 0 0 0 0 0
max_n 0 20 15 19 18
n 20 (14, 27) 6 (1, 17) 7 (2, 18) 9 (4, 20) 9 (4, 20)
n_unique 19 (13, 25) 5 (1, 16) 6 (2, 17) 8 (3, 18) 8 (3, 18)
post_p NA (NA, NA) 0.47 (0.19, 0.84) 0.44 (0.17, 0.82) 0.48 (0.17, 0.83) 0.44 (0.17, 0.84)
rate 0.114 (0.079, 0.16) 0.124 (0.074, 0.306) 0.127 (0.071, 0.294) 0.121 (0.08, 0.26) 0.122 (0.08, 0.242)
-++- graduation 0 79 62 54 53
futility 0 0 0 0 0
max_n 0 1 11 7 12
n 11 (7, 16) 5 (1, 11) 5 (2, 11) 6 (3, 12) 6 (3, 12)
n_unique 10 (6, 15) 4 (1, 10) 4 (1, 10) 6 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.48 (0.22, 0.8) 0.47 (0.23, 0.82) 0.47 (0.2, 0.81) 0.45 (0.2, 0.8)
rate 0.114 (0.071, 0.182) 0.127 (0.065, 0.307) 0.125 (0.064, 0.323) 0.126 (0.072, 0.292) 0.13 (0.073, 0.299)
-+++ graduation 0 102 89 72 76
futility 0 0 0 0 0
max_n 0 1 10 7 11
n 11 (7, 17) 5 (1, 11) 5 (1, 10) 6 (2, 13) 6 (2, 13)
n_unique 10 (6, 16) 4 (1, 10) 4 (1, 9) 5 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.48 (0.24, 0.78) 0.44 (0.23, 0.77) 0.46 (0.22, 0.83) 0.48 (0.21, 0.8)
rate 0.113 (0.074, 0.188) 0.124 (0.07, 0.334) 0.13 (0.069, 0.366) 0.125 (0.067, 0.27) 0.124 (0.072, 0.329)
+— graduation 0 20 7 4 3
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 19 (14, 26) 8 (3, 17) 11 (5, 21) 9 (3, 18) 8 (3, 17)
n_unique 18 (12, 24) 7 (3, 16) 10 (4, 19) 8 (2, 16) 7 (2, 16)
post_p NA (NA, NA) 0.44 (0.18, 0.81) 0.49 (0.18, 0.85) 0.44 (0.18, 0.82) 0.46 (0.18, 0.81)
rate 0.114 (0.078, 0.157) 0.128 (0.08, 0.254) 0.116 (0.077, 0.229) 0.125 (0.079, 0.299) 0.122 (0.075, 0.303)
+–+ graduation 0 47 50 33 34
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 15 (10, 21) 7 (2, 15) 8 (3, 16) 7 (2, 15) 7 (2, 13)
n_unique 14 (9, 20) 6 (2, 14) 7 (3, 14) 6 (2, 13) 6 (2, 12)
post_p NA (NA, NA) 0.46 (0.2, 0.82) 0.44 (0.18, 0.84) 0.45 (0.2, 0.79) 0.44 (0.21, 0.83)
rate 0.113 (0.076, 0.165) 0.126 (0.075, 0.323) 0.122 (0.074, 0.289) 0.126 (0.072, 0.318) 0.125 (0.071, 0.33)
+-+- graduation 0 58 43 32 30
futility 0 0 0 0 0
max_n 0 1 11 7 12
n 15 (10, 21) 7 (2, 14) 8 (3, 16) 6 (2, 14) 7 (3, 15)
n_unique 14 (9, 20) 6 (2, 13) 7 (3, 14) 6 (2, 13) 6 (2, 13)
post_p NA (NA, NA) 0.48 (0.21, 0.83) 0.46 (0.18, 0.82) 0.44 (0.2, 0.81) 0.49 (0.21, 0.85)
rate 0.116 (0.082, 0.17) 0.124 (0.072, 0.278) 0.128 (0.076, 0.25) 0.133 (0.073, 0.346) 0.12 (0.071, 0.276)
+-++ graduation 0 83 72 54 58
futility 0 0 0 0 0
max_n 0 1 10 7 11
n 15 (10, 22) 6 (2, 14) 8 (3, 16) 7 (3, 15) 7 (2, 15)
n_unique 14 (9, 20) 6 (2, 12) 7 (3, 15) 6 (2, 13) 6 (2, 14)
post_p NA (NA, NA) 0.41 (0.2, 0.81) 0.45 (0.19, 0.82) 0.47 (0.18, 0.83) 0.46 (0.2, 0.83)
rate 0.112 (0.078, 0.166) 0.131 (0.074, 0.331) 0.126 (0.076, 0.249) 0.121 (0.073, 0.278) 0.124 (0.075, 0.319)
++– graduation 0 44 36 30 30
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 11 (7, 16) 5 (2, 10) 5 (2, 11) 6 (2, 12) 6 (2, 12)
n_unique 10 (6, 15) 4 (1, 9) 4 (2, 10) 6 (2, 11) 6 (2, 11)
post_p NA (NA, NA) 0.46 (0.22, 0.8) 0.44 (0.21, 0.76) 0.44 (0.19, 0.8) 0.45 (0.21, 0.79)
rate 0.112 (0.072, 0.178) 0.126 (0.066, 0.344) 0.137 (0.071, 0.356) 0.129 (0.072, 0.308) 0.132 (0.078, 0.3)
++-+ graduation 0 69 70 52 55
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 11 (7, 16) 5 (2, 10) 5 (2, 11) 6 (2, 12) 6 (2, 12)
n_unique 10 (6, 15) 4 (1, 9) 5 (1, 10) 5 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.48 (0.24, 0.79) 0.47 (0.23, 0.79) 0.45 (0.2, 0.79) 0.47 (0.2, 0.8)
rate 0.117 (0.072, 0.176) 0.123 (0.069, 0.289) 0.127 (0.07, 0.336) 0.133 (0.07, 0.344) 0.124 (0.07, 0.317)
+++- graduation 0 79 62 54 53
futility 0 0 0 0 0
max_n 0 1 11 7 12
n 11 (7, 16) 5 (1, 11) 5 (2, 11) 6 (2, 12) 6 (2, 12)
n_unique 10 (6, 15) 4 (1, 10) 4 (1, 10) 6 (2, 11) 6 (2, 11)
post_p NA (NA, NA) 0.5 (0.23, 0.79) 0.44 (0.24, 0.82) 0.45 (0.21, 0.8) 0.47 (0.22, 0.81)
rate 0.115 (0.075, 0.189) 0.121 (0.065, 0.328) 0.131 (0.063, 0.34) 0.131 (0.073, 0.321) 0.124 (0.075, 0.283)
++++ graduation 0 102 89 72 76
futility 0 0 0 0 0
max_n 0 1 10 7 11
n 12 (7, 17) 5 (1, 10) 5 (1, 11) 6 (2, 12) 6 (2, 13)
n_unique 10 (6, 16) 4 (1, 9) 5 (1, 10) 5 (2, 11) 5 (2, 12)
post_p NA (NA, NA) 0.45 (0.22, 0.78) 0.46 (0.23, 0.8) 0.46 (0.2, 0.8) 0.46 (0.21, 0.82)
rate 0.111 (0.075, 0.171) 0.134 (0.07, 0.35) 0.124 (0.066, 0.345) 0.126 (0.073, 0.304) 0.125 (0.072, 0.328)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 9 5 3 2
time_stop 4 (4, 5) 7 (4, 9) 5 (5, 11) 11 (9, 13)
n_trt 30 (26, 31) 33 (31, 47) 25 (25, 67) 70 (56, 85)
n_control 50 (36, 62) 67 (51, 103) 57 (55, 114) 111 (98, 124)
post_p 0.9 (0.86, 0.94) 0.97 (0.97, 0.99) 0.96 (0.92, 0.99) 0.94 (0.9, 0.99)
order 1 (1, 1) 1 (1, 1) 1 (1, 1) 1.5 (1.1, 1.9)
TP53- & AR- count 53 37 23 31
time_stop 10 (6, 20) 13 (10, 26) 12 (10, 19) 17 (10, 27)
n_trt 31 (25, 56) 34 (26, 73) 30 (25, 60) 37 (25, 71)
n_control 39 (28, 83) 55 (40, 111) 55 (36, 87) 69 (41, 112)
post_p 0.91 (0.86, 0.95) 0.94 (0.88, 0.98) 0.92 (0.86, 0.98) 0.94 (0.88, 0.99)
order 1 (1, 1) 1 (1, 1.4) 1 (1, 1.8) 1 (1, 2)
TP53+ count 13 5 2 5
time_stop 11 (8, 14) 12 (9, 16) 12 (11, 12) 11 (8, 24)
n_trt 34 (27, 42) 43 (25, 49) 32 (31, 34) 28 (26, 85)
n_control 53 (35, 62) 51 (37, 67) 43 (41, 45) 45 (36, 113)
post_p 0.96 (0.88, 0.98) 0.95 (0.91, 0.97) 0.96 (0.94, 0.98) 0.95 (0.9, 1)
order 1 (1, 1) 1 (1, 1) 1.5 (1.1, 1.9) 1 (1, 1)
DRD+ count 6 1 3 1
time_stop 18 (16, 24) 21 (21, 21) 11 (9, 13) 11 (11, 11)
n_trt 30 (26, 42) 29 (29, 29) 25 (25, 27) 26 (26, 26)
n_control 46 (36, 66) 54 (54, 54) 36 (20, 38) 39 (39, 39)
post_p 0.98 (0.93, 1) 0.99 (0.99, 0.99) 0.99 (0.95, 0.99) 0.96 (0.96, 0.96)
order 1 (1, 1.5) 1 (1, 1) 1 (1, 1.8) 1 (1, 1)
TEfus+ count 5 5 1 6
time_stop 15 (10, 20) 15 (9, 22) 9 (9, 9) 12 (10, 14)
n_trt 26 (25, 39) 28 (25, 57) 27 (27, 27) 33 (28, 37)
n_control 56 (41, 67) 52 (40, 93) 27 (27, 27) 46 (36, 52)
post_p 0.95 (0.94, 0.98) 0.96 (0.96, 0.98) 1 (1, 1) 0.96 (0.86, 0.98)
order 1 (1, 2.6) 1 (1, 1.6) 1 (1, 1) 1 (1, 2)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 11 2 1 1
time_stop 5 (4, 6) 5 (5, 5) 8 (8, 8) 8 (8, 8)
n_trt 33 (28, 44) 30 (28, 32) 34 (34, 34) 38 (38, 38)
n_control 47 (39, 65) 54 (53, 54) 74 (74, 74) 70 (70, 70)
post_p 0.1 (0.02, 0.27) 0.15 (0.09, 0.21) 0.02 (0.02, 0.02) 0.04 (0.04, 0.04)
order 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 132 121 134 125
time_stop 16 (8, 30) 21 (12, 32) 22 (13, 33) 23 (13, 34)
n_trt 36 (26, 71) 32 (26, 78) 38 (25, 87) 37 (25, 83)
n_control 70 (31, 139) 95 (53, 157) 101 (55, 161) 102 (57, 168)
post_p 0.18 (0.07, 0.28) 0.14 (0.04, 0.28) 0.15 (0.04, 0.26) 0.14 (0.04, 0.26)
order 1 (1, 3) 1 (1, 3) 2 (1, 3) 2 (1, 3)
TP53+ count 26 31 26 22
time_stop 19 (9, 26) 19 (10, 34) 22 (14, 32) 22 (16, 34)
n_trt 40 (25, 62) 42 (29, 83) 47 (30, 72) 45 (33, 62)
n_control 84 (40, 130) 92 (38, 172) 108 (54, 159) 111 (73, 175)
post_p 0.07 (0.01, 0.19) 0.04 (0.01, 0.13) 0.05 (0.01, 0.16) 0.05 (0, 0.17)
order 1 (1, 2.5) 2 (1, 4) 2 (1, 4) 2 (1, 3)
DRD+ count 18 28 24 26
time_stop 27 (20, 34) 30 (21, 34) 21 (11, 30) 21 (13, 32)
n_trt 30 (25, 42) 34 (26, 46) 34 (25, 44) 33 (26, 46)
n_control 76 (41, 97) 82 (59, 110) 60 (24, 87) 57 (34, 86)
post_p 0.07 (0.04, 0.26) 0.05 (0.03, 0.22) 0.05 (0.02, 0.25) 0.05 (0.01, 0.12)
order 2 (1, 4) 2 (1, 5) 2 (1, 3.7) 2 (1, 3)
TEfus+ count 23 38 28 25
time_stop 21 (13, 33) 22 (11, 34) 23 (14, 31) 23 (16, 35)
n_trt 35 (26, 48) 42 (27, 72) 38 (26, 51) 44 (31, 72)
n_control 83 (48, 134) 90 (36, 136) 86 (49, 141) 83 (53, 128)
post_p 0.08 (0, 0.18) 0.09 (0.01, 0.17) 0.05 (0.01, 0.21) 0.06 (0.01, 0.14)
order 2 (1, 3) 2 (1, 4) 2 (1, 4) 2 (1, 3.6)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
time 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5)
n 14 (11, 16) 2 (1, 3) 7 (5, 8) 2 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 2 (0, 3) 1 (0, 3) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.6 (0.54, 0.67) 0.54 (0.52, 0.56) 0.6 (0.53, 0.69) 0.54 (0.52, 0.6) 0.51 (0.51, 0.51) 0.53 (0.51, 0.6) 0.54 (0.54, 0.54) NA (NA, NA) 0.56 (0.52, 0.58) 0.56 (0.51, 0.61) 0.53 (0.53, 0.53) 0.5 (0.5, 0.5) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.056 (0, 0.092) 0 (0, 0.046) 0 (0, 0.08) 0 (0, 0.055) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0.036) 0 (0, 0.126) 0.261 (0.125, 0.396) 0.124 (0.025, 0.224) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0)
Taxel_therapies count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
time 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9) 7 (4, 9)
n 8 (3, 12) 2 (0, 4) 5 (3, 9) 8 (6, 9) 1 (0, 2) 1 (0, 3) 0 (0, 0) 0 (0, 1) 4 (0, 5) 2 (1, 3) 2 (0, 3) 2 (1, 3) 1 (0, 2) 0 (0, 4) 1 (0, 2) 1 (0, 1)
post_p 0.69 (0.54, 0.73) 0.56 (0.52, 0.59) 0.56 (0.54, 0.72) 0.66 (0.5, 0.73) 0.63 (0.56, 0.7) 0.54 (0.53, 0.58) NA (NA, NA) 0.56 (0.54, 0.58) 0.57 (0.56, 0.57) 0.57 (0.56, 0.6) 0.58 (0.55, 0.64) 0.59 (0.51, 0.61) 0.55 (0.54, 0.58) 0.55 (0.55, 0.55) 0.53 (0.52, 0.55) 0.52 (0.52, 0.53)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.046 (0.014, 0.12) 0.03 (0, 0.143) 0 (0, 0.134) 0.072 (0.052, 0.108) 0 (0, 0) 0 (0, 0.114) NA (NA, NA) 0 (0, 0) 0.02 (0, 0.051) 0 (0, 0.066) 0 (0, 0) 0 (0, 0.026) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Carboplatin count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11) 5 (5, 11)
n 3 (2, 13) 2 (0, 2) 3 (3, 14) 2 (0, 8) 3 (1, 5) 4 (2, 6) 2 (0, 4) 1 (0, 2) 0 (0, 2) 2 (0, 3) 1 (0, 2) 2 (1, 3) 3 (1, 3) 1 (0, 3) 3 (1, 5) 0 (0, 2)
post_p 0.6 (0.57, 0.9) 0.57 (0.54, 0.59) 0.62 (0.6, 0.7) 0.52 (0.51, 0.53) 0.67 (0.55, 0.79) 0.7 (0.61, 0.75) 0.59 (0.52, 0.65) 0.57 (0.56, 0.59) 0.64 (0.64, 0.64) 0.53 (0.52, 0.54) 0.56 (0.54, 0.58) 0.56 (0.55, 0.59) 0.52 (0.5, 0.54) 0.53 (0.53, 0.54) 0.55 (0.53, 0.57) 0.69 (0.69, 0.69)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.042 (0.008, 0.076) 0 (0, 0.055) 0.048 (0.01, 0.087) 0.067 (0.013, 0.188) 0.069 (0.014, 0.104) 0.047 (0.009, 0.084) 0 (0, 0) 0 (0, 0) 0.046 (0.009, 0.084) 0 (0, 0) 0 (0, 0.084) 0 (0, 0) 0.054 (0.011, 0.096) 0.029 (0.006, 0.052) 0 (0, 0)
Niraparib count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13)
n 19 (13, 25) 5 (3, 7) 7 (6, 8) 3 (2, 4) 2 (1, 2) 3 (2, 4) 4 (3, 5) 3 (2, 4) 2 (2, 2) 2 (2, 2) 3 (2, 4) 2 (1, 4) 2 (2, 3) 3 (2, 4) 4 (3, 6) 6 (4, 7)
post_p 0.76 (0.7, 0.82) 0.54 (0.51, 0.57) 0.62 (0.61, 0.63) 0.62 (0.61, 0.62) 0.58 (0.54, 0.61) 0.65 (0.57, 0.72) 0.58 (0.53, 0.62) 0.58 (0.52, 0.65) 0.58 (0.53, 0.64) 0.58 (0.54, 0.63) 0.62 (0.54, 0.71) 0.65 (0.65, 0.65) 0.54 (0.52, 0.56) 0.61 (0.58, 0.64) 0.75 (0.69, 0.82) 0.6 (0.59, 0.6)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.071 (0.053, 0.089) 0.089 (0.059, 0.118) 0.086 (0.08, 0.092) 0.036 (0.007, 0.065) 0.026 (0.005, 0.046) 0 (0, 0) 0.058 (0.012, 0.105) 0.125 (0.075, 0.174) 0.116 (0.023, 0.209) 0.067 (0.013, 0.12) 0.107 (0.058, 0.157) 0.037 (0.037, 0.037) 0.186 (0.121, 0.252) 0.088 (0.018, 0.159) 0.045 (0.009, 0.081) 0.08 (0.016, 0.145)
TP53- & AR- Hormone_therapies count 53 53 53 53
time 10 (6, 20) 10 (6, 20) 10 (6, 20) 10 (6, 20)
n 25 (19, 39) 4 (2, 9) 2 (0, 5) 2 (0, 5)
post_p 0.8 (0.71, 0.93) 0.59 (0.51, 0.77) 0.6 (0.53, 0.73) 0.57 (0.53, 0.75)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.082 (0.046, 0.106) 0.084 (0, 0.133) 0 (0, 0.142) 0 (0, 0.119)
Taxel_therapies count 37 37 37 37
time 13 (10, 26) 13 (10, 26) 13 (10, 26) 13 (10, 26)
n 22 (17, 45) 5 (2, 12) 3 (0, 11) 4 (1, 9)
post_p 0.83 (0.73, 0.94) 0.64 (0.53, 0.82) 0.65 (0.51, 0.76) 0.67 (0.54, 0.82)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.079 (0.047, 0.1) 0.073 (0, 0.122) 0.067 (0, 0.127) 0.071 (0, 0.1)
Carboplatin count 23 23 23 23
time 12 (10, 19) 12 (10, 19) 12 (10, 19) 12 (10, 19)
n 20 (12, 46) 3 (1, 7) 4 (2, 10) 4 (2, 11)
post_p 0.83 (0.72, 0.93) 0.59 (0.51, 0.73) 0.58 (0.52, 0.85) 0.7 (0.53, 0.84)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.068 (0.037, 0.098) 0.031 (0, 0.11) 0.078 (0.005, 0.122) 0.047 (0.003, 0.122)
Niraparib count 31 31 31 31
time 17 (10, 27) 17 (10, 27) 17 (10, 27) 17 (10, 27)
n 24 (13, 45) 4 (1, 8) 5 (2, 13) 5 (2, 14)
post_p 0.86 (0.72, 0.94) 0.62 (0.52, 0.85) 0.65 (0.54, 0.84) 0.68 (0.52, 0.8)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.08 (0.05, 0.091) 0.057 (0, 0.1) 0.082 (0, 0.119) 0.07 (0, 0.127)
TP53+ Hormone_therapies count 13 13 13 13 13 13 13 13
time 11 (8, 14) 11 (8, 14) 11 (8, 14) 11 (8, 14) 11 (8, 14) 11 (8, 14) 11 (8, 14) 11 (8, 14)
n 15 (11, 25) 7 (3, 10) 1 (0, 2) 1 (0, 3) 2 (1, 5) 3 (0, 4) 1 (0, 4) 1 (0, 3)
post_p 0.8 (0.73, 0.91) 0.75 (0.62, 0.84) 0.6 (0.52, 0.65) 0.56 (0.53, 0.67) 0.56 (0.52, 0.64) 0.59 (0.51, 0.74) 0.56 (0.53, 0.69) 0.57 (0.53, 0.66)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.069 (0.04, 0.084) 0.044 (0, 0.089) 0 (0, 0.094) 0 (0, 0) 0.059 (0, 0.134) 0.071 (0, 0.181) 0 (0, 0.08) 0 (0, 0.104)
Taxel_therapies count 5 5 5 5 5 5 5 5
time 12 (9, 16) 12 (9, 16) 12 (9, 16) 12 (9, 16) 12 (9, 16) 12 (9, 16) 12 (9, 16) 12 (9, 16)
n 13 (8, 16) 11 (7, 17) 3 (1, 5) 1 (0, 2) 2 (1, 5) 4 (1, 6) 1 (0, 3) 2 (0, 5)
post_p 0.8 (0.6, 0.83) 0.78 (0.65, 0.86) 0.63 (0.55, 0.75) 0.53 (0.51, 0.55) 0.55 (0.51, 0.66) 0.55 (0.51, 0.68) 0.56 (0.56, 0.59) 0.53 (0.52, 0.64)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.054 (0.044, 0.077) 0.072 (0.064, 0.09) 0.028 (0, 0.079) 0 (0, 0.058) 0.048 (0, 0.122) 0.064 (0.015, 0.083) 0 (0, 0.071) 0.046 (0, 0.113)
Carboplatin count 2 2 2 2 2 2 2 2
time 12 (11, 12) 12 (11, 12) 12 (11, 12) 12 (11, 12) 12 (11, 12) 12 (11, 12) 12 (11, 12) 12 (11, 12)
n 10 (6, 14) 5 (3, 7) 4 (4, 5) 0 (0, 1) 3 (3, 3) 4 (3, 5) 4 (3, 5) 2 (1, 2)
post_p 0.66 (0.54, 0.78) 0.77 (0.71, 0.82) 0.67 (0.62, 0.72) 0.53 (0.53, 0.53) 0.62 (0.58, 0.66) 0.55 (0.53, 0.57) 0.63 (0.57, 0.69) 0.6 (0.53, 0.67)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.068 (0.065, 0.07) 0.016 (0.003, 0.029) 0.063 (0.045, 0.082) 0 (0, 0) 0.044 (0.009, 0.079) 0.08 (0.074, 0.086) 0.06 (0.055, 0.065) 0 (0, 0)
Niraparib count 5 5 5 5 5 5 5 5
time 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24)
n 13 (6, 31) 5 (2, 15) 3 (3, 4) 4 (1, 7) 2 (1, 6) 3 (1, 9) 3 (1, 6) 5 (3, 8)
post_p 0.8 (0.75, 0.95) 0.55 (0.53, 0.72) 0.56 (0.56, 0.63) 0.56 (0.53, 0.67) 0.6 (0.51, 0.84) 0.55 (0.52, 0.75) 0.58 (0.55, 0.74) 0.63 (0.56, 0.75)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.045 (0, 0.076) 0.09 (0.029, 0.11) 0.072 (0.024, 0.112) 0.046 (0, 0.106) 0 (0, 0.058) 0.096 (0.027, 0.13) 0 (0, 0.086) 0.062 (0.036, 0.082)
DRD+ Hormone_therapies count 6 6 6 6 6 6 6 6
time 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24)
n 9 (5, 11) 6 (3, 10) 3 (1, 3) 4 (2, 6) 2 (2, 4) 3 (2, 4) 4 (0, 4) 4 (1, 6)
post_p 0.78 (0.64, 0.89) 0.73 (0.57, 0.92) 0.64 (0.61, 0.73) 0.64 (0.56, 0.76) 0.53 (0.51, 0.59) 0.58 (0.52, 0.64) 0.56 (0.53, 0.65) 0.69 (0.58, 0.84)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.068 (0.039, 0.075) 0.068 (0.026, 0.127) 0.047 (0, 0.058) 0.04 (0, 0.107) 0.085 (0.038, 0.104) 0 (0, 0.061) 0.051 (0.017, 0.144) 0.011 (0, 0.05)
Taxel_therapies count 1 1 1 1 1 1 1 1
time 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21)
n 5 (5, 5) 7 (7, 7) 5 (5, 5) 5 (5, 5) 1 (1, 1) 2 (2, 2) 4 (4, 4) 0 (0, 0)
post_p 0.76 (0.76, 0.76) 0.79 (0.79, 0.79) 0.88 (0.88, 0.88) 0.82 (0.82, 0.82) 0.57 (0.57, 0.57) 0.75 (0.75, 0.75) 0.56 (0.56, 0.56) NA (NA, NA)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.105 (0.105, 0.105) 0.085 (0.085, 0.085) 0.083 (0.083, 0.083) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.046 (0.046, 0.046) NA (NA, NA)
Carboplatin count 3 3 3 3 3 3 3 3
time 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13)
n 4 (4, 6) 5 (2, 5) 4 (3, 5) 2 (2, 3) 3 (1, 4) 3 (2, 5) 4 (2, 5) 2 (0, 2)
post_p 0.69 (0.64, 0.8) 0.7 (0.64, 0.83) 0.53 (0.52, 0.64) 0.55 (0.53, 0.59) 0.55 (0.55, 0.64) 0.58 (0.55, 0.59) 0.57 (0.52, 0.58) 0.6 (0.54, 0.67)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.06 (0.045, 0.066) 0.037 (0.007, 0.098) 0.071 (0.07, 0.089) 0 (0, 0.074) 0.133 (0.027, 0.197) 0.038 (0.008, 0.093) 0.058 (0.047, 0.208) 0 (0, 0)
Niraparib count 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 3 (3, 3) 3 (3, 3) 4 (4, 4) 4 (4, 4) 3 (3, 3) 2 (2, 2) 5 (5, 5) 2 (2, 2)
post_p 0.65 (0.65, 0.65) 0.52 (0.52, 0.52) 0.7 (0.7, 0.7) 0.58 (0.58, 0.58) 0.55 (0.55, 0.55) 0.56 (0.56, 0.56) 0.59 (0.59, 0.59) 0.55 (0.55, 0.55)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.078 (0.078, 0.078) 0.097 (0.097, 0.097) 0.11 (0.11, 0.11) 0.155 (0.155, 0.155) 0 (0, 0) 0.033 (0.033, 0.033) 0 (0, 0)
TEfus+ Hormone_therapies count 5 5 5 5 5 5 5 5
time 15 (10, 20) 15 (10, 20) 15 (10, 20) 15 (10, 20) 15 (10, 20) 15 (10, 20) 15 (10, 20) 15 (10, 20)
n 2 (2, 6) 7 (5, 15) 1 (1, 5) 3 (1, 5) 3 (2, 7) 4 (0, 8) 2 (2, 3) 1 (0, 3)
post_p 0.61 (0.54, 0.76) 0.75 (0.71, 0.81) 0.63 (0.56, 0.74) 0.57 (0.52, 0.62) 0.66 (0.6, 0.81) 0.66 (0.56, 0.82) 0.56 (0.52, 0.67) 0.6 (0.58, 0.65)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.065 (0.017, 0.089) 0.073 (0.064, 0.074) 0 (0, 0.097) 0.056 (0, 0.134) 0.059 (0.023, 0.105) 0.053 (0.013, 0.084) 0.075 (0, 0.205) 0 (0, 0.057)
Taxel_therapies count 5 5 5 5 5 5 5 5
time 15 (9, 22) 15 (9, 22) 15 (9, 22) 15 (9, 22) 15 (9, 22) 15 (9, 22) 15 (9, 22) 15 (9, 22)
n 5 (4, 12) 13 (11, 14) 5 (2, 6) 1 (0, 3) 1 (0, 9) 5 (2, 11) 2 (0, 4) 0 (0, 1)
post_p 0.71 (0.58, 0.79) 0.77 (0.72, 0.87) 0.62 (0.55, 0.69) 0.57 (0.52, 0.65) 0.58 (0.53, 0.78) 0.87 (0.56, 0.9) 0.54 (0.51, 0.65) 0.63 (0.63, 0.63)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.067 (0.011, 0.089) 0.063 (0.041, 0.097) 0 (0, 0.091) 0.045 (0, 0.1) 0.08 (0.016, 0.115) 0.071 (0.02, 0.124) 0.04 (0, 0.115) 0 (0, 0)
Carboplatin count 1 1 1 1 1 1 1 1
time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
n 4 (4, 4) 4 (4, 4) 8 (8, 8) 2 (2, 2) 3 (3, 3) 2 (2, 2) 2 (2, 2) 2 (2, 2)
post_p 0.76 (0.76, 0.76) 0.76 (0.76, 0.76) 0.78 (0.78, 0.78) 0.56 (0.56, 0.56) 0.55 (0.55, 0.55) 0.57 (0.57, 0.57) 0.66 (0.66, 0.66) 0.52 (0.52, 0.52)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.086 (0.086, 0.086) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 6 6 6 6 6 6 6 6
time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
n 2 (1, 8) 5 (4, 11) 6 (4, 10) 3 (1, 4) 4 (2, 4) 3 (2, 7) 4 (1, 4) 2 (2, 5)
post_p 0.6 (0.55, 0.73) 0.63 (0.56, 0.75) 0.67 (0.52, 0.92) 0.52 (0.51, 0.56) 0.56 (0.52, 0.66) 0.62 (0.59, 0.76) 0.69 (0.62, 0.71) 0.56 (0.52, 0.73)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0.061) 0.077 (0.071, 0.094) 0.088 (0.07, 0.149) 0.015 (0, 0.097) 0.058 (0, 0.138) 0 (0, 0.058) 0.074 (0.017, 0.092) 0.061 (0, 0.236)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
time 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6)
n 14 (12, 20) 3 (2, 3) 8 (6, 13) 3 (2, 5) 0 (0, 1) 0 (0, 1) 0 (0, 2) 0 (0, 1) 2 (0, 3) 0 (0, 2) 1 (0, 3) 0 (0, 5) 0 (0, 1) 0 (0, 2) 0 (0, 1) 0 (0, 0)
post_p 0.37 (0.13, 0.48) 0.47 (0.42, 0.49) 0.39 (0.37, 0.48) 0.44 (0.34, 0.48) 0.45 (0.42, 0.49) 0.45 (0.45, 0.45) 0.48 (0.48, 0.48) 0.3 (0.3, 0.3) 0.44 (0.27, 0.47) 0.4 (0.28, 0.41) 0.45 (0.37, 0.48) 0.44 (0.35, 0.46) 0.44 (0.42, 0.47) 0.45 (0.27, 0.47) 0.37 (0.31, 0.43) 0.48 (0.48, 0.48)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.193 (0.087, 0.287) 0.229 (0.139, 0.392) 0.158 (0.084, 0.274) 0.216 (0, 0.285) 0.691 (0.041, 34.89) 1.121 (0.36, 1.882) 0 (0, 0.087) 4.95 (1.153, 8.747) 0.221 (0.087, 0.696) 0.586 (0.387, 0.638) 0.165 (0, 0.289) 0.235 (0.178, 0.486) 0 (0, 0.31) 0.266 (0, 0.639) 0 (0, 0.157) 0 (0, 0)
Taxel_therapies count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
n 4 (3, 5) 1 (0, 2) 8 (8, 8) 6 (4, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 4 (2, 6) 1 (0, 2) 2 (1, 2) 2 (1, 4) 0 (0, 1) 1 (0, 2) 0 (0, 0) 0 (0, 1)
post_p 0.46 (0.44, 0.47) 0.47 (0.47, 0.47) 0.35 (0.27, 0.42) 0.47 (0.44, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.49 (0.49, 0.49) 0.46 (0.45, 0.46) 0.36 (0.36, 0.36) 0.44 (0.44, 0.44) 0.47 (0.47, 0.47) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.194 (0.194, 0.194) 0.189 (0.189, 0.189) 0.187 (0.164, 0.209) 0.193 (0.168, 0.218) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.17 (0.142, 0.198) 1.804 (1.804, 1.804) 0.158 (0.032, 0.284) 0.054 (0.011, 0.097) 0 (0, 0) 0 (0, 0) NA (NA, NA) 2.366 (2.366, 2.366)
Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 12 (12, 12) 0 (0, 0) 4 (4, 4) 2 (2, 2) 4 (4, 4) 4 (4, 4) 0 (0, 0) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 4 (4, 4) 0 (0, 0) 0 (0, 0)
post_p 0.32 (0.32, 0.32) NA (NA, NA) 0.47 (0.47, 0.47) 0.33 (0.33, 0.33) 0.45 (0.45, 0.45) 0.48 (0.48, 0.48) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.46 (0.46, 0.46) 0.38 (0.38, 0.38) NA (NA, NA) NA (NA, NA)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.144 (0.144, 0.144) NA (NA, NA) 0.1 (0.1, 0.1) 5.488 (5.488, 5.488) 0.148 (0.148, 0.148) 0.094 (0.094, 0.094) NA (NA, NA) 0.117 (0.117, 0.117) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.288 (0.288, 0.288) 0.293 (0.293, 0.293) NA (NA, NA) NA (NA, NA)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 3 (3, 3) 0 (0, 0) 11 (11, 11) 6 (6, 6) 4 (4, 4) 5 (5, 5) 1 (1, 1) 2 (2, 2) 1 (1, 1) 1 (1, 1) 0 (0, 0) 1 (1, 1) 1 (1, 1) 2 (2, 2) 0 (0, 0) 0 (0, 0)
post_p 0.49 (0.49, 0.49) NA (NA, NA) 0.47 (0.47, 0.47) 0.46 (0.46, 0.46) 0.46 (0.46, 0.46) 0.33 (0.33, 0.33) 0.46 (0.46, 0.46) 0.4 (0.4, 0.4) 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) NA (NA, NA) 0.43 (0.43, 0.43) 0.5 (0.5, 0.5) 0.41 (0.41, 0.41) NA (NA, NA) NA (NA, NA)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.156 (0.156, 0.156) NA (NA, NA) 0.109 (0.109, 0.109) 0.135 (0.135, 0.135) 0.157 (0.157, 0.157) 0.246 (0.246, 0.246) 0.224 (0.224, 0.224) 1.23 (1.23, 1.23) 0.505 (0.505, 0.505) 1.058 (1.058, 1.058) NA (NA, NA) 0.356 (0.356, 0.356) 0.317 (0.317, 0.317) 0.195 (0.195, 0.195) NA (NA, NA) NA (NA, NA)
TP53- & AR- Hormone_therapies count 132 132 132 132
time 16 (8, 30) 16 (8, 30) 16 (8, 30) 16 (8, 30)
n 26 (17, 53) 5 (3, 10) 3 (1, 9) 3 (0, 8)
post_p 0.32 (0.13, 0.47) 0.39 (0.21, 0.48) 0.4 (0.22, 0.48) 0.4 (0.23, 0.48)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.125 (0.102, 0.17) 0.137 (0.088, 0.342) 0.178 (0.1, 0.539) 0.182 (0.11, 0.709)
Taxel_therapies count 121 121 121 121
time 21 (12, 32) 21 (12, 32) 21 (12, 32) 21 (12, 32)
n 17 (10, 59) 6 (3, 13) 4 (1, 12) 4 (1, 11)
post_p 0.35 (0.1, 0.47) 0.36 (0.17, 0.48) 0.41 (0.2, 0.49) 0.38 (0.22, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.131 (0.106, 0.207) 0.164 (0.105, 0.363) 0.161 (0.109, 0.379) 0.169 (0.111, 0.397)
Carboplatin count 134 134 134 134
time 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33)
n 20 (8, 57) 5 (2, 13) 6 (3, 12) 6 (3, 13)
post_p 0.35 (0.1, 0.47) 0.39 (0.22, 0.48) 0.36 (0.18, 0.48) 0.36 (0.18, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.133 (0.103, 0.201) 0.159 (0.113, 0.412) 0.156 (0.104, 0.388) 0.147 (0.097, 0.326)
Niraparib count 125 125 125 125
time 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34)
n 18 (7, 53) 5 (2, 13) 6 (3, 15) 7 (3, 15)
post_p 0.33 (0.11, 0.47) 0.37 (0.19, 0.49) 0.36 (0.2, 0.48) 0.36 (0.17, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.134 (0.108, 0.232) 0.157 (0.105, 0.398) 0.148 (0.102, 0.299) 0.151 (0.112, 0.334)
TP53+ Hormone_therapies count 26 26 26 26 26 26 26 26
time 19 (9, 26) 19 (9, 26) 19 (9, 26) 19 (9, 26) 19 (9, 26) 19 (9, 26) 19 (9, 26) 19 (9, 26)
n 14 (8, 28) 8 (4, 15) 3 (0, 5) 2 (0, 6) 4 (1, 7) 3 (0, 6) 2 (0, 5) 1 (0, 4)
post_p 0.36 (0.14, 0.42) 0.3 (0.12, 0.46) 0.44 (0.25, 0.5) 0.42 (0.33, 0.49) 0.45 (0.26, 0.49) 0.35 (0.24, 0.46) 0.39 (0.32, 0.48) 0.42 (0.3, 0.47)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.136 (0.096, 0.194) 0.153 (0.098, 0.29) 0.208 (0.1, 0.475) 0.204 (0.126, 0.771) 0.157 (0.088, 0.318) 0.211 (0.102, 0.446) 0.199 (0.116, 1.882) 0.206 (0.108, 0.441)
Taxel_therapies count 31 31 31 31 31 31 31 31
time 19 (10, 34) 19 (10, 34) 19 (10, 34) 19 (10, 34) 19 (10, 34) 19 (10, 34) 19 (10, 34) 19 (10, 34)
n 11 (6, 20) 12 (7, 22) 2 (0, 6) 3 (1, 6) 6 (3, 11) 6 (2, 9) 3 (1, 9) 2 (0, 7)
post_p 0.33 (0.06, 0.44) 0.32 (0.13, 0.47) 0.37 (0.2, 0.46) 0.42 (0.33, 0.48) 0.38 (0.16, 0.49) 0.36 (0.18, 0.47) 0.38 (0.27, 0.49) 0.42 (0.24, 0.48)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.14 (0.099, 0.205) 0.14 (0.094, 0.224) 0.248 (0.102, 1.601) 0.173 (0.117, 0.877) 0.161 (0.1, 0.243) 0.144 (0.091, 0.477) 0.223 (0.107, 0.46) 0.192 (0.095, 0.65)
Carboplatin count 26 26 26 26 26 26 26 26
time 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32)
n 12 (5, 30) 8 (4, 16) 3 (1, 6) 4 (2, 9) 3 (2, 8) 4 (2, 8) 4 (2, 8) 4 (2, 6)
post_p 0.31 (0.15, 0.45) 0.31 (0.15, 0.44) 0.39 (0.15, 0.47) 0.38 (0.19, 0.48) 0.39 (0.22, 0.48) 0.37 (0.23, 0.47) 0.41 (0.2, 0.49) 0.4 (0.23, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.146 (0.1, 0.255) 0.18 (0.1, 0.336) 0.165 (0.089, 0.673) 0.175 (0.079, 0.709) 0.202 (0.112, 0.445) 0.204 (0.12, 0.366) 0.162 (0.107, 0.405) 0.185 (0.116, 0.44)
Niraparib count 22 22 22 22 22 22 22 22
time 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34)
n 9 (6, 22) 10 (4, 16) 4 (1, 6) 3 (2, 6) 4 (2, 7) 4 (1, 9) 4 (2, 8) 4 (1, 8)
post_p 0.24 (0.09, 0.44) 0.38 (0.17, 0.46) 0.38 (0.21, 0.49) 0.33 (0.17, 0.48) 0.34 (0.2, 0.47) 0.32 (0.22, 0.46) 0.38 (0.23, 0.49) 0.4 (0.14, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.173 (0.109, 0.366) 0.139 (0.114, 0.319) 0.186 (0.109, 0.324) 0.196 (0.107, 0.459) 0.154 (0.101, 0.415) 0.205 (0.128, 0.518) 0.17 (0.11, 0.355) 0.167 (0.093, 0.411)
DRD+ Hormone_therapies count 18 18 18 18 18 18 18 18
time 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34)
n 5 (2, 10) 4 (2, 10) 4 (1, 5) 3 (1, 9) 4 (1, 6) 4 (1, 6) 4 (1, 6) 4 (1, 5)
post_p 0.4 (0.22, 0.49) 0.38 (0.28, 0.48) 0.4 (0.33, 0.48) 0.42 (0.23, 0.5) 0.42 (0.28, 0.48) 0.41 (0.23, 0.48) 0.39 (0.27, 0.47) 0.32 (0.2, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.159 (0.119, 0.343) 0.179 (0.121, 0.717) 0.158 (0.109, 0.369) 0.147 (0.097, 0.657) 0.171 (0.12, 0.286) 0.162 (0.116, 0.353) 0.134 (0.105, 0.354) 0.182 (0.123, 0.372)
Taxel_therapies count 28 28 28 28 28 28 28 28
time 30 (21, 34) 30 (21, 34) 30 (21, 34) 30 (21, 34) 30 (21, 34) 30 (21, 34) 30 (21, 34) 30 (21, 34)
n 6 (1, 11) 5 (2, 11) 3 (1, 6) 2 (0, 5) 3 (1, 7) 3 (1, 6) 4 (2, 8) 4 (2, 7)
post_p 0.39 (0.23, 0.48) 0.28 (0.14, 0.49) 0.37 (0.28, 0.47) 0.38 (0.27, 0.46) 0.37 (0.23, 0.46) 0.41 (0.24, 0.48) 0.44 (0.29, 0.49) 0.36 (0.26, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.147 (0.113, 0.258) 0.204 (0.114, 0.419) 0.166 (0.115, 0.782) 0.173 (0.12, 0.427) 0.206 (0.121, 0.504) 0.168 (0.093, 0.623) 0.16 (0.105, 0.336) 0.153 (0.105, 0.343)
Carboplatin count 24 24 24 24 24 24 24 24
time 21 (11, 30) 21 (11, 30) 21 (11, 30) 21 (11, 30) 21 (11, 30) 21 (11, 30) 21 (11, 30) 21 (11, 30)
n 4 (2, 9) 6 (2, 11) 3 (1, 6) 4 (1, 6) 4 (1, 7) 4 (1, 6) 4 (2, 7) 4 (1, 7)
post_p 0.39 (0.18, 0.49) 0.37 (0.18, 0.47) 0.41 (0.18, 0.45) 0.37 (0.21, 0.49) 0.41 (0.25, 0.48) 0.42 (0.28, 0.49) 0.37 (0.23, 0.49) 0.38 (0.2, 0.49)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.186 (0.104, 0.433) 0.172 (0.108, 0.31) 0.165 (0.115, 0.435) 0.17 (0.075, 0.27) 0.157 (0.102, 0.389) 0.181 (0.115, 0.33) 0.152 (0.087, 0.415) 0.187 (0.109, 0.416)
Niraparib count 26 26 26 26 26 26 26 26
time 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32)
n 5 (3, 10) 5 (3, 9) 4 (2, 10) 3 (1, 6) 3 (1, 8) 3 (1, 8) 4 (2, 7) 4 (1, 8)
post_p 0.34 (0.17, 0.47) 0.38 (0.16, 0.48) 0.37 (0.15, 0.48) 0.39 (0.3, 0.46) 0.38 (0.26, 0.48) 0.38 (0.23, 0.48) 0.35 (0.23, 0.47) 0.36 (0.21, 0.47)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.157 (0.119, 0.361) 0.17 (0.105, 0.307) 0.187 (0.111, 0.358) 0.19 (0.118, 0.569) 0.187 (0.098, 0.488) 0.177 (0.117, 0.503) 0.181 (0.094, 0.519) 0.184 (0.108, 0.953)
TEfus+ Hormone_therapies count 23 23 23 23 23 23 23 23
time 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33)
n 6 (3, 9) 10 (4, 16) 3 (0, 6) 3 (1, 8) 3 (2, 6) 3 (2, 8) 3 (1, 6) 2 (0, 5)
post_p 0.36 (0.16, 0.44) 0.35 (0.22, 0.47) 0.4 (0.17, 0.46) 0.43 (0.25, 0.5) 0.38 (0.22, 0.46) 0.34 (0.19, 0.44) 0.41 (0.24, 0.48) 0.4 (0.24, 0.49)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.158 (0.108, 0.37) 0.142 (0.115, 0.259) 0.145 (0.109, 0.885) 0.17 (0.101, 0.445) 0.198 (0.104, 0.558) 0.268 (0.12, 0.666) 0.149 (0.116, 0.58) 0.167 (0.13, 0.427)
Taxel_therapies count 38 38 38 38 38 38 38 38
time 22 (11, 34) 22 (11, 34) 22 (11, 34) 22 (11, 34) 22 (11, 34) 22 (11, 34) 22 (11, 34) 22 (11, 34)
n 6 (2, 14) 12 (7, 24) 3 (1, 8) 3 (0, 6) 5 (2, 10) 4 (2, 9) 2 (0, 6) 3 (1, 6)
post_p 0.35 (0.14, 0.47) 0.35 (0.16, 0.45) 0.4 (0.17, 0.49) 0.42 (0.27, 0.49) 0.36 (0.25, 0.49) 0.34 (0.24, 0.46) 0.41 (0.28, 0.48) 0.4 (0.22, 0.49)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.167 (0.113, 0.477) 0.127 (0.085, 0.162) 0.155 (0.102, 0.662) 0.165 (0.096, 0.999) 0.156 (0.101, 0.357) 0.159 (0.098, 0.434) 0.163 (0.125, 0.432) 0.184 (0.115, 0.644)
Carboplatin count 28 28 28 28 28 28 28 28
time 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31) 23 (14, 31)
n 4 (1, 10) 8 (4, 13) 6 (3, 9) 4 (2, 10) 4 (1, 5) 4 (1, 8) 4 (1, 6) 4 (3, 7)
post_p 0.38 (0.23, 0.48) 0.36 (0.1, 0.49) 0.34 (0.23, 0.48) 0.42 (0.22, 0.49) 0.39 (0.26, 0.45) 0.42 (0.21, 0.48) 0.39 (0.26, 0.46) 0.36 (0.23, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.167 (0.102, 0.384) 0.161 (0.089, 0.338) 0.165 (0.101, 0.475) 0.167 (0.08, 0.373) 0.181 (0.107, 0.336) 0.15 (0.092, 0.3) 0.218 (0.105, 0.414) 0.171 (0.108, 0.403)
Niraparib count 25 25 25 25 25 25 25 25
time 23 (16, 35) 23 (16, 35) 23 (16, 35) 23 (16, 35) 23 (16, 35) 23 (16, 35) 23 (16, 35) 23 (16, 35)
n 4 (2, 9) 7 (4, 23) 5 (3, 10) 4 (2, 8) 4 (1, 9) 5 (2, 12) 4 (1, 11) 3 (1, 9)
post_p 0.33 (0.15, 0.47) 0.27 (0.14, 0.46) 0.31 (0.13, 0.46) 0.38 (0.21, 0.47) 0.4 (0.21, 0.48) 0.42 (0.26, 0.49) 0.4 (0.2, 0.49) 0.41 (0.22, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.204 (0.122, 0.665) 0.151 (0.113, 0.257) 0.167 (0.117, 0.294) 0.153 (0.107, 0.351) 0.163 (0.094, 0.493) 0.157 (0.083, 0.322) 0.157 (0.101, 0.416) 0.158 (0.085, 0.452)